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Comment
. 2022 Apr 11;40(4):346-348.
doi: 10.1016/j.ccell.2022.03.003. Epub 2022 Mar 24.

CD8+ T cells PUF(A)ing the flames of cancer ferroptotic cell death

José Pedro Friedmann Angeli  1 , Thamara Nishida Xavier da Silva  2 , Bastian Schilling  3
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CD8+ T cells PUF(A)ing the flames of cancer ferroptotic cell death

José Pedro Friedmann Angeli et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Liao et al. demonstrate that CD8+ T cell-secreted interferon-gamma (IFN-γ) rewires cancer cell lipid metabolism via the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4). ACSL4 activates polyunsaturated fatty acids and sensitizes cancer cells to ferroptosis in immunotherapy-relevant settings. These findings provide insights into how the metabolic and immune milieu could be used to promote ferroptosis.

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Declaration of interests The authors declare no competing interests.

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