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. 2022 Apr 11;40(4):362-364.
doi: 10.1016/j.ccell.2022.03.002. Epub 2022 Mar 24.

Innate lymphoid cells recruit T cells to turn up the heat on tumors

Kingston H G Mills  1
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Innate lymphoid cells recruit T cells to turn up the heat on tumors

Kingston H G Mills. Cancer Cell. .
Free article

Abstract

In a recent publication in Nature Immunology, Bruchard et al. report that type 3 innate lymphoid cells, activated and recruited by cisplatin-induced chemokine ligand 20 (CCL20) and interleukin-1 beta (IL-1β), promote CD4 and CD8 T cell infiltration into murine tumors. This turns "cold" tumors "hot", thereby enhancing responsiveness to immune checkpoint inhibitors.

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Conflict of interest statement

Declaration of interests Kingston Mills is a co-founder and shareholder in a biotech start-up company that is involved in the development of anti-inflammatory therapeutics.

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