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. 2022 Feb 27;10(3):373.
doi: 10.3390/vaccines10030373.

Gender and AB0 Blood Type Differences in a Unicentric Group of University Professors in Southern Italy Who Received the Vaxzevria COVID-19 Vaccine: A Cross-Sectional Survey of Vaccine Side Effects, Attitudes, and Hesitation

Silvana Mirella Aliberti  1 , Luigi Schiavo  1 , Giovanni Boccia  1   2 , Emanuela Santoro  1 , Gianluigi Franci  1   2 , Alessandro Ruggiero  3 , Francesco De Caro  1   2 , Mario Capunzo  1   2
Affiliations

Gender and AB0 Blood Type Differences in a Unicentric Group of University Professors in Southern Italy Who Received the Vaxzevria COVID-19 Vaccine: A Cross-Sectional Survey of Vaccine Side Effects, Attitudes, and Hesitation

Silvana Mirella Aliberti et al. Vaccines (Basel). .

Abstract

Vaccination has been a key protective behavior for COVID-19. This study investigated the clinical status of university professors administered the Vaxzevria COVID-19 vaccine, to monitor for any adverse reaction, and to understand attitude and hesitancy to vaccination. Data were collected through an online survey. The study received approval from the relevant ethics committee "Comitato Etico Campania Sud". Multivariate logistic regressions were used to calculate significant predictors of the outcomes of interest. A gender and AB0 blood type difference in adverse vaccine reactions was found. The multivariate logistic regression model showed that female gender, city residence, blood type A+ and B-, and chronic underlying medical conditions or comorbidities were more strongly implicated in the occurrence of adverse reactions, whereas blood type 0 Rh+ or blood type A Rh- were protective factors of adverse reactions to the Vaxzevria vaccine. Both genders did not show serious adverse reactions to the Vaxzevria vaccine. Based on our results, we are able to support the hypothesis that AB0 blood type and gender difference appear as predictors of Vaxzevria COVID-19 vaccine reactogenicity. Furthermore, in the study population, the degree of concern and hesitation to undergo vaccination was minimal.

Keywords: AB0 blood type; Vaxzevria vaccine; attitudes; gender difference; hesitancy; side effects; university professors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survey design, including data collection, participant recruitment, and objectives. Note: For more information look at the introduction, study design and results.
Figure 2
Figure 2
Difference in health perception after the first and second doses of Vaxzevria on the outcome of males and females.
See this image and copyright information in PMC

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