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Review
. 2022 Mar 10;27(6):1803.
doi: 10.3390/molecules27061803.

Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy

Jiayao Li  1 , Yinan Liu  1 , Hend E Abdelhakim  1
Affiliations
Review

Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy

Jiayao Li et al. Molecules. .

Abstract

Cancer is one of the most serious health problems and the second leading cause of death worldwide, and with an ageing and growing population, problems related to cancer will continue. In the battle against cancer, many therapies and anticancer drugs have been developed. Chemotherapy and relevant drugs are widely used in clinical practice; however, their applications are always accompanied by severe side effects. In recent years, the drug delivery system has been improved by nanotechnology to reduce the adverse effects of the delivered drugs. Among the different candidates, core-sheath nanofibres prepared by coaxial electrospinning are outstanding due to their unique properties, including their large surface area, high encapsulation efficiency, good mechanical property, multidrug loading capacity, and ability to govern drug release kinetics. Therefore, encapsulating drugs in coaxial electrospun nanofibres is a desirable method for controlled and sustained drug release. This review summarises the drug delivery applications of coaxial electrospun nanofibres with different structures and drugs for various cancer treatments.

Keywords: applications; cancer therapy; coaxial nanofibres; drug delivery; electrospinning.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of a coaxial electrospinning setup.
Figure 2
Figure 2
A schematic illustration of this experimental strategy. Created with BioRender.com and adapted from [51].
Figure 3
Figure 3
Sonication-triggered drug release. (a) Attachment of nanoparticles onto the surface of nanofibre, (b) embedding of nanoparticles by solvent vapor annealing, and (c) nanoparticles detached by ultrasonication-triggered drug release. Created with BioRender.com and adapted from [34].
Figure 4
Figure 4
The transdermal nanofibre platform containing paclitaxel-loaded PCPP-CA micelles synthesised by coaxial electrospinning. Created with BioRender.com and adapted from [67].
Figure 5
Figure 5
Comparison of drug release process and kinetics between (a,b) solid film and (c,d) multi-layered fibre membrane wafer. Created with BioRender.com and adapted from [70].
Figure 6
Figure 6
Schematic diagram of core–sheath nanofibre transporting 5-FC and the suicide gene. Created with BioRender.com and adapted from [77].
See this image and copyright information in PMC

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