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. 2022 Mar 11;27(6):1847.
doi: 10.3390/molecules27061847.

Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

Paulo Wender P Gomes  1   2 , Hugo Barretto  2 , José Diogo E Reis  2 , Abraão Muribeca  2 , Alice Veloso  2 , Carlos Albuquerque  2 , Andrew Teixeira  3 , Wandson Braamcamp  2 , Sônia Pamplona  2 , Consuelo Silva  2   4 , Milton Silva  2
Affiliations

Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

Paulo Wender P Gomes et al. Molecules. .

Abstract

Peperomia pellucida is a species known in the Amazon as "erva-de-jabuti" that has been used in several therapeutic applications based on folk medicine. Herein, we describe the classes, subclasses, and the main compounds of the leaves, stems, and roots from P. pellucida by ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry associated with molecular networks, mirror plot on the GNPS library, and machine learning. These data show compounds that were annotated for the first time in the Peperomia genus, such as 2',4',5'-trihydroxybutyrophenonevelutin, dehydroretrofractamide C, and retrofractamide B.

Keywords: LC-MS/MS; Piperaceae; Sirius; machine learning; molecular network.

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Conflict of interest statement

We declare no current or potential conflict of interest related to this article.

Figures

Figure 1
Figure 1
(A) Classification of compounds classes and subclasses of the ethanolic extract from P. pellucida leaves, stem, and roots using MolNetEnhancer [34]; (B) Some examples of propagated annotation using Sirius 4 [35].
Figure 2
Figure 2
Characteristic losses of portions of hexose in flavonoids (e.g., MS/MS spectrum to Isoschaftoside and Luteolin-6-C-glucoside-8-C-arabinoside). Both mass spectra are available by QR code.
Figure 3
Figure 3
Selected clusters and annotation of compounds from the molecular network in positive ion mode for the ethanolic extract of the leaves, stem, and roots from P. pellucida. Numbers beside the nodes correspond to the accurate precursor mass (m/z), red circle: MS2 match on GNPS library, node color blue correspondent to leaves, yellow correspondent to stem, and blue correspondent to roots.
See this image and copyright information in PMC

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