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. 2022 Mar 17;14(6):1207.
doi: 10.3390/polym14061207.

Employing Cellulose Nanofiber-Based Hydrogels for Burn Dressing

Aliakbar Tofangchi Kalle Basti  1 , Mehdi Jonoobi  1   2 , Sima Sepahvand  1 , Alireza Ashori  3 , Valentina Siracusa  4 , Davood Rabie  5 , Tizazu H Mekonnen  2 , Fatemeh Naeijian  6
Affiliations

Employing Cellulose Nanofiber-Based Hydrogels for Burn Dressing

Aliakbar Tofangchi Kalle Basti et al. Polymers (Basel). .

Abstract

The aim of this research was to fabricate a burn dressing in the form of hydrogel films constructed with cellulose nanofibers (CNF) that has pain-relieving properties, in addition to wound healing. In this study, the hydrogels were prepared in the form of film. For this, CNF at weight ratios of 1, 2, and 3 wt.%, 1 wt.% of hydroxyethyl cellulose (HEC), and citric acid (CA) crosslinker with 10 and 20 wt.% were used. FE-SEM analysis showed that the structure of the CNF was preserved after hydrogel preparation. Cationization of CNF by C6H14NOCl was confirmed by FTIR spectroscopy. The drug release analysis results showed a linear relationship between the amount of absorption and the concentration of the drug. The MTT test (assay protocol for cell viability and proliferation) showed the high effectiveness of cationization of CNF and confirmed the non-toxicity of the resulting hydrogels.

Keywords: burn dressing; cellulose nanofibers; cross-linker; hydrogel.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Image of a hydrogel with a ratio of CNF/HEC (3:1 wt.%) and CA 20 wt.% ((A): in the dry sample and (B) in the wet sample).
Figure 2
Figure 2
FTIR spectra of the control and group A samples.
Figure 3
Figure 3
Changes in gel fraction at different times.
Figure 4
Figure 4
FE-SEM images of C3 and C6 hydrogels.
Figure 5
Figure 5
Changes in the elastic and loss modulus of C3 and C6 hydrogels relative to frequency.
Figure 6
Figure 6
(A) Calibration curve of silver nitrate adsorption at 230 nm relative to the concentration and (B) Cumulative percentage of silver nitrate release from hydrogels A3 and A6 relative to time.
See this image and copyright information in PMC

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