Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar 17;14(6):1218.
doi: 10.3390/polym14061218.

Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications

Mia Arifka  1 , Gofarana Wilar  2 , Khaled M Elamin  3 , Nasrul Wathoni  1
Affiliations
Review

Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications

Mia Arifka et al. Polymers (Basel). .

Abstract

Secretomes of mesenchymal stem cells (MSCs) have been successfully studied in preclinical models for several biomedical applications, including tissue engineering, drug delivery, and cancer therapy. Hydrogels are known to imitate a three-dimensional extracellular matrix to offer a friendly environment for stem cells; therefore, hydrogels can be used as scaffolds for tissue construction, to control the distribution of bioactive compounds in tissues, and as a secretome-producing MSC culture media. The administration of a polymeric hydrogel-based MSC secretome has been shown to overcome the fast clearance of the target tissue. In vitro studies confirm the bioactivity of the secretome encapsulated in the gel, allowing for a controlled and sustained release process. The findings reveal that the feasibility of polymeric hydrogels as MSC -secretome delivery systems had a positive influence on the pace of tissue and organ regeneration, as well as an enhanced secretome production. In this review, we discuss the widely used polymeric hydrogels and their advantages as MSC secretome delivery systems in biomedical applications.

Keywords: biomedical application; mesenchymal stem cell secretome; polymeric hydrogel; secretome delivery systems.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Quantification of journals in this review.
Figure 2
Figure 2
Scheme of the Mechanism of Action of MSCs.
See this image and copyright information in PMC

References

    1. Bari E., Ferrarotti I., Torre M.L., Corsico A.G., Perteghella S. Mesenchymal stem/stromal cell secretome for lung regeneration: The long way through “pharmaceuticalization” for the best formulation. J. Control. Release. 2019;309:11–24. doi: 10.1016/j.jconrel.2019.07.022. - DOI - PubMed
    1. Conese M., Cassano R., Gavini E., Trapani G., Rassu G., Sanna E., Di Gioia S., Trapani A. Harnessing Stem Cells and Neurotrophic Factors with Novel Technologies in the Treatment of Parkinson’s Disease. Curr. Stem Cell Res. Ther. 2019;14:549–569. doi: 10.2174/1574888X14666190301150210. - DOI - PubMed
    1. Zavala G., Ramos M.P., Figueroa-Valdés A.I., Cisternas P., Wyneken U., Hernández M., Toa P., Salmons B., Dangerfield J., Gunzburg W.H., et al. Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (SEV) From Encapsulated Cells. Front. Pharmacol. 2020;11:679. doi: 10.3389/fphar.2020.00679. - DOI - PMC - PubMed
    1. Chaubey S., Thueson S., Ponnalagu D., Alam M.A., Gheorghe C.P., Aghai Z., Singh H., Bhandari V. Early Gestational Mesenchymal Stem Cell Secretome Attenuates Experimental Bronchopulmonary Dysplasia in Part via Exosome-Associated Factor TSG-6. Stem Cell Res. Ther. 2018;9:173. doi: 10.1186/s13287-018-0903-4. - DOI - PMC - PubMed
    1. Vizoso F.J., Eiro N., Cid S., Schneider J., Perez-Fernandez R. Mesenchymal stem cell secretome: Toward cell-free therapeutic strategies in regenerative medicine. Int. J. Mol. Sci. 2017;18:1852. doi: 10.3390/ijms18091852. - DOI - PMC - PubMed

Grants and funding

LinkOut - more resources