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Review
. 2022 Feb 27;11(3):300.
doi: 10.3390/pathogens11030300.

Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

Felipe Francisco Tuon  1 , Leticia Ramos Dantas  1 , Paula Hansen Suss  1 , Victoria Stadler Tasca Ribeiro  1
Affiliations
Review

Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

Felipe Francisco Tuon et al. Pathogens. .

Abstract

Pseudomonas aeruginosa is associated with several human infections, mainly related to healthcare services. In the hospital, it is associated with resistance to several antibiotics, which poses a great challenge to therapy. However, one of the biggest challenges in treating P. aeruginosa infections is that related to biofilms. The complex structure of the P. aeruginosa biofilm contributes an additional factor to the pathogenicity of this microorganism, leading to therapeutic failure, in addition to escape from the immune system, and generating chronic infections that are difficult to eradicate. In this review, we address several molecular aspects of the pathogenicity of P. aeruginosa biofilms.

Keywords: Pseudomonas aeruginosa; biofilm; quorum sensing; virulence.

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Conflict of interest statement

F. F. Tuon is a CNPq researcher. The other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of main infections caused by Pseudomonas aeruginosa.
Figure 2
Figure 2
Biofilm formed by Pseudomonas aeruginosa on an orthopedical device. (A)—Clinical infection after exposure tibial fracture; (B)—Biofilm identification using scanning electronic microscopy in the orthopedic screw of the same patient; (C,D)—P. aeruginosa biofilm in the surgical screw under greater magnifications. Source: authors.
Figure 3
Figure 3
Genes of the quorum sensing systems of Pseudomonas aeruginosa with regulatory looping and molecules associated with biofilms and pathogenicity.
See this image and copyright information in PMC

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