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Review
. 2022 Mar 17;11(3):368.
doi: 10.3390/pathogens11030368.

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

Affiliations
Review

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

Nasruddeen Al-Awwal et al. Pathogens. .

Abstract

Development and deployment of biosensors for the rapid detection of the 2019 novel severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) are of utmost importance and urgency during this recent outbreak of coronavirus pneumonia (COVID-19) caused by SARS-CoV-2 infection, which spread rapidly around the world. Cases now confirmed in February 2022 indicate that more than 170 countries worldwide are affected. Recent evidence indicates over 430 million confirmed cases with over 5.92 million deaths scattered across the globe, with the United States having more than 78 million confirmed cases and over 920,000 deaths. The US now has many more cases than in China where coronavirus cases were first reported in late December 2019. During the initial outbreak in China, many leaders did not anticipate it could reach the whole world, spreading to many countries and posing severe threats to global health. The objective of this review is to summarize the origin of COVID-19, its biological nature, comparison with other coronaviruses, symptoms, prevention, treatment, potential, available methods for SARS-CoV-2 detection, and post-COVID-19 symptoms.

Keywords: COVID-19; MERS-CoV; SARS-CoV-2 (2019-nCoV); infection; outbreak; rapid detection; symptoms.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Fehr R.A., Perlman S. Coronaviruses. Humana Press; New York, NY, USA: 2015. Coronaviruses: An overview of their replication and pathogenesis; pp. 1–23. - PMC - PubMed
    1. Ross J., Sun L. Ninety days in: A comprehensive review of the ongoing COVID-19 outbreak. Health Sci. J. 2020;14:706.
    1. Sheahan T.P., Sims A.C., Leist S.R., Schäfer A., Won J., Brown A.J., Montgomery S.A., Hogg A., Babusis D., Clarke M.O., et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat. Commun. 2020;11:222. doi: 10.1038/s41467-019-13940-6. - DOI - PMC - PubMed
    1. Yadav R., Chaudhary J.K., Jain N., Chaudhary P.K., Khanra S., Dhamija P., Sharma A., Kumar A., Handu S. Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19. Cells. 2021;10:821. doi: 10.3390/cells10040821. - DOI - PMC - PubMed
    1. Zheng J. SARS-CoV-2: An emerging coronavirus that causes a global threat. Int. J. Biol. Sci. 2020;16:1678. doi: 10.7150/ijbs.45053. - DOI - PMC - PubMed

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