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Review
. 2022 Mar 22;26(1):76.
doi: 10.1186/s13054-022-03911-7.

Vasopressor Choice and Timing in Vasodilatory Shock

Patrick M Wieruszewski  1 , Ashish K Khanna  2   3
Affiliations
Review

Vasopressor Choice and Timing in Vasodilatory Shock

Patrick M Wieruszewski et al. Crit Care. .

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2022 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/bookseries/8901 .

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Conflict of interest statement

PMW has previously received consulting fees from La Jolla Pharmaceutical Company. AKK received consulting fees and grant funding from La Jolla Pharmaceutical Company. AKK consults for Edwards Lifesciences, Medtronic, Potrero Medical, GE Healthcare, Philips North America, Caretaker Medical and Retia Medical. He is funded by an NIH/NCATS KL2 award for assessment of blood pressure and oxygenation in postoperative patients and a Wake Forest Hypertension and Vascular Research award for studying the relationship between serum renin and outcomes in patients with septic shock.

Figures

Fig. 1
Fig. 1
Pathogenic mechanisms leading to refractory vasodilatory shock. ATP adenosine tri-phosphate, cGMP cyclic guanosine monophosphate, COX-2 cyclooxygenase-2, PGI2 prostaglandin I2, ROS reactive oxygen species. (From [8] with permission)
Fig. 2
Fig. 2
Physiologic concert of the adrenergic, vasopressinergic, and renin-angiotensin systems in blood pressure homeostasis, and select mechanisms of pharmacologic vasopressors. α1 alpha1-adrenergic receptor, AT1R angiotensin type 1 receptor, β1 beta1-adrenergic receptor, β2 beta2-adrenergic receptor, V1 vasopressin 1 receptor. (Used with permission of Mayo Foundation for Medical Education and Research, all rights reserved)
See this image and copyright information in PMC

References

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    1. Scheeren TWL, Bakker J, De Backer D, et al. Current use of vasopressors in septic shock. Ann Intensive Care. 2019;9:20. - PMC - PubMed

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