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. 2022:107:41-77.
doi: 10.1016/bs.acc.2021.07.002. Epub 2021 Aug 23.

Host polymorphisms and COVID-19 infection

Joris R Delanghe  1 , Marijn M Speeckaert  2
Affiliations

Host polymorphisms and COVID-19 infection

Joris R Delanghe et al. Adv Clin Chem. 2022.

Abstract

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). There is growing evidence that host genetics play an important role in COVID-19 severity. Based on current knowledge about the human protein machinery for SARS-CoV-2 entry, the host innate immune response, and virus-host interactions, the potential effects of human genetic polymorphisms, which may contribute to clinical differences in SARS-CoV-2 pathogenesis, may help to determine the individual risk for COVID-19 infection and outcome.

Keywords: COVID-19; Host; Mortality; Polymorphisms; Prevalence.

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