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Review
. 2022 Jun;44(6):e2100284.
doi: 10.1002/bies.202100284. Epub 2022 Mar 25.

Inheritance and maintenance of small RNA-mediated epigenetic effects

Piergiuseppe Quarato  1 , Meetali Singh  1 , Loan Bourdon  1 , Germano Cecere  1
Affiliations
Review

Inheritance and maintenance of small RNA-mediated epigenetic effects

Piergiuseppe Quarato et al. Bioessays. 2022 Jun.

Abstract

Heritable traits are predominantly encoded within genomic DNA, but it is now appreciated that epigenetic information is also inherited through DNA methylation, histone modifications, and small RNAs. Several examples of transgenerational epigenetic inheritance of traits have been documented in plants and animals. These include even the inheritance of traits acquired through the soma during the life of an organism, implicating the transfer of epigenetic information via the germline to the next generation. Small RNAs appear to play a significant role in carrying epigenetic information across generations. This review focuses on how epigenetic information in the form of small RNAs is transmitted from the germline to the embryos through the gametes. We also consider how inherited epigenetic information is maintained across generations in a small RNA-dependent and independent manner. Finally, we discuss how epigenetic traits acquired from the soma can be inherited through small RNAs.

Keywords: RNA interference; chromatin; epigenetic inheritance; epigenetics; small RNAs; transgenerational inheritance.

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References

REFERENCES

    1. Slatkin, M. (2009). Epigenetic inheritance and the missing heritability problem. Genetics, 182(3), 845-850. https://doi.org/10.1534/genetics.109.102798
    1. Duempelmann, L., Skribbe, M., & Bühler, M. (2020). Small RNAs in the transgenerational inheritance of epigenetic information. Trends in Genetics, 36(3), 203-214. https://doi.org/10.1016/j.tig.2019.12.001
    1. Stuwe, E., Tóth, K. F., & Aravin, A. A. (2014). Small but sturdy: Small RNAs in cellular memory and epigenetics. Genes & development, 28(5), 423-431. https://doi.org/10.1101/gad.236414.113
    1. Skvortsova, K., Iovino, N., & Bogdanović, O. (2018). Functions and mechanisms of epigenetic inheritance in animals. Nature Reviews Molecular Cell Biology, 19(12), 774-790. https://doi.org/10.1038/s41580-018-0074-2
    1. Cecere, G. (2021). Small RNAs in epigenetic inheritance: From mechanisms to trait transmission. Febs Letters, 595(24), 2953. https://doi.org/10.1002/1873-3468.14210

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