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Review
. 2022 Sep;47(9):1703-1706.
doi: 10.1111/ced.15196. Epub 2022 May 22.

Superimposed type 2 segmental atopic dermatitis: case series and review of the literature

Efrat Bar-Ilan  1 , Jacob Mashiah  1   2   3 , Ronen Alkalay  4 , Arieh Ingber  4 , Keren Or Zahavi  1 , Jonathan Bar  1 , Tal Zeeli  1 , Andrea Gat  5 , Liat Samuelov  1   2   3 , Eli Sprecher  1   2   3 , Ilan Goldberg  1   3
Affiliations
Review

Superimposed type 2 segmental atopic dermatitis: case series and review of the literature

Efrat Bar-Ilan et al. Clin Exp Dermatol. 2022 Sep.

Abstract

Generalized acquired dermatoses can seldom manifest more prominently or exclusively along the lines of Blaschko. Six individuals with segmental atopic dermatitis (AD) have been reported to date. We present three additional cases of segmental cutaneous manifestations superimposed on generalized AD, and review the relevant literature.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
(a–d) Patient 1: linear rash on left popliteal fossa and medial aspect of the foot composed of papules and plaques covered with scales, crust and lichenification. (e,f) Patient 3: linear rash on the left thigh, leg and ankle composed of erythematous papules and plaques with an impressive rope‐like lichenification. [Colour figure can be viewed at wileyonlinelibrary.com]
Figure 2
Figure 2
(a,b) Patient 1: hyperkeratosis with foci of parakeratosis, extensive spongiosis, preserved stratum granulosum and extensive perivascular infiltrates. (c,d) Patient 2: perivascular, spongiotic psoriasiform dermatitis with orthohyperkeratosis and focal parakeratosis, compatible with lichen simplex superimposed on atopic dermatitis. (e,f) Patient 3: irregular acanthosis, packed hyperkeratosis and parakeratosis, marked spongiosis, and perivascular and interstitial infiltrates. Haematoxylin and eosin, original magnification (a) × 20; (b) × 40; (c) × 10; (d) × 20; (e) × 10; (f) × 20. [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

References

    1. Taieb A. Linear atopic dermatitis (‘naevus atopicus’): a pathogenetic clue? Br J Dermatol 1994; 131: 134–5. - PubMed
    1. Hladik F, Jurecka W, Hayek B et al. Atopic dermatitis with increased severity along a line of Blaschko. J Am Acad Dermatol 2005; 53: S221–4. - PubMed
    1. López‐Cedeño A, Noguera‐Morel L, Hernández‐Martín A et al. Superimposed linear atopic dermatitis. Pediatr Dermatol 2018; 35: e393–5. - PubMed
    1. Blaschko A. Die Nervenverteilung in Der Haut in Ihrerbeziehungzu Den Erkrnkungen Der Haut. Leipzig: Braumüller, 1901.
    1. Hauber K, Ross C, Brocker EB, Hamm H. Lichen striatus: clinical features an follow‐up in 12 patients. Eur J Dermatol 2000; 10: 536–9. - PubMed

MeSH terms