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. 2022 Mar 21:16:749-757.
doi: 10.2147/DDDT.S352876. eCollection 2022.

Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects

Hui-Ping Duan  1 , Rong Liu  2
Affiliations

Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects

Hui-Ping Duan et al. Drug Des Devel Ther. .

Abstract

Background: Open-angle glaucoma is a common ophthalmic disease, which has a great impact on the vision of middle-aged and elderly people. Medication plays an important role in the treatment of glaucoma, so finding effective drug treatment is of great significance to improve the quality of life of glaucoma patients.

Objective: To explore the curative effect of nimodipine combined with latanoprost in the treatment of open-angle glaucoma and its effect on ocular hemodynamics and visual field defects.

Methods: This study retrospectively analyzed the clinical data of 87 patients with open-angle glaucoma who came to the Shanxi Province Fenyang Hospital and The First Affiliated Hospital of Shanxi Datong University for treatment from January 2019 to January 2021. According to different treatment plans, the patients were divided into two groups: an observation group (n = 46) treated with nimodipine combined with latanoprost, and a control group (n = 41) treated by latanoprost monotherapy. Treatment efficacy, hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters, adverse reactions and quality of life were recorded and compared between two groups of patients.

Results: The overall therapeutic effect of the observation group was significantly better than that in the control group. After treatment, ocular hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters and life quality of both groups were obviously improved compared to those before treatment, with more significant improvements in the observation group. In addition, there was no significant difference in the incidence of adverse reactions between the two groups.

Conclusion: Nimodipine combined with latanoprost eye drops is effective in the treatment of primary open-angle glaucoma, which could effectively improve the ocular hemodynamics and visual field defects of patients with fewer adverse reactions and higher safety. Therefore, it can be further promoted and used in clinical practice.

Keywords: degree of visual field defects; latanoprost; nimodipine; ocular hemodynamics; open-angle glaucoma.

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Conflict of interest statement

The authors declare no competing interests in this work.

Figures

Figure 1
Figure 1
Comparison of ocular hemodynamic indicators between the two groups; (A) comparison of PSV between the two groups before and after treatment; (B) comparison of EDV between the two groups before and after treatment; (C) comparison of RI between the two groups before and after treatment. *Indicates P<0.05.
Figure 2
Figure 2
Comparison of visual field defects between the two groups; (A) comparison of upper visual field between the two groups before and after treatment; (B) comparison of lower visual field between the two groups before and after treatment; (C) comparison of temporal visual field between the two groups before and after treatment; (D) comparison of nasal visual field between the two groups before and after treatment. *Indicates P<0.05.
Figure 3
Figure 3
Comparison of binocular optic disc parameters between the two groups; (A) comparison of vertical C/D between the two groups before and after treatment; (B) comparison of average C/D between the two groups before and after treatment; (C) comparison of MD between the two groups before and after treatment; (D) comparison of RA values between the two groups before and after treatment. *Indicates P<0.05.
See this image and copyright information in PMC

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