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Review
. 2022 Feb 14;18(5):1829-1843.
doi: 10.7150/ijbs.66917. eCollection 2022.

Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Ying-Bing Zuo  1   2 , Yin-Feng Zhang  2 , Rui Zhang  1 , Jia-Wei Tian  3 , Xiao-Bing Lv  1 , Rong Li  1 , Shu-Ping Li  4 , Meng-Die Cheng  1   2 , Jing Shan  2   5   6 , Zheng Zhao  1   2 , Hui Xin  1
Affiliations
Review

Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Ying-Bing Zuo et al. Int J Biol Sci. .

Abstract

Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation. Notable studies have revealed that ferroptosis plays vital roles in tumor occurrence and that abundant ferroptosis in cells can inhibit tumor progression. Recently, some noncoding RNAs (ncRNAs), particularly microRNAs, long noncoding RNAs, and circular RNAs, have been shown to be involved in biological processes of ferroptosis, thus affecting cancer growth. However, the definite regulatory mechanism of this phenomenon is still unclear. To clarify this issue, increasing studies have focused on the regulatory roles of ncRNAs in the initiation and development of ferroptosis and the role of ferroptosis in progression of various cancers, such as lung, liver, and breast cancers. In this review, we systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression. Moreover, additional evidence is needed to identify the role of ferroptosis-related ncRNAs in cancer progression. This review will help us to understand the roles of ncRNAs in ferroptosis and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.

Keywords: Cell death; Ferroptosis; circular RNAs; long noncoding RNAs; microRNAs.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
The molecular mechanism of ferroptosis. Cys2: Cysteine; Glu: Glutamate; SLC7A11: Solute carrier family 7 membrane 11; SLC3A2: Solute carrier family 3 membrane 2; SLC40A1: Solute carrier family 40 membrane 1; TFRC: Transferrin receptor; GSH: Reduced glutathione; GPX4: Glutathione peroxidase 4; GSR: Glutathione reductase; GSSG: Oxidized Glutathione; ROS: Reactive oxygen species; AA: Arachidonic acid; ACSL4: Acyl-CoA synthetase long-chain family member 4; LPCAT3: lysophophatidylcholne acyltransferase 3; ALOXs: Lipoxygenases
Fig 2
Fig 2
MiRNAs and lncRNAs play regulatory role in ferroptosis. Cys2: Cysteine; GSH: Reduced glutathione; SLC3A2: Solute carrier family 3 membrane 2; SLC7A11: Solute carrier family 7 membrane 11; GPX4: Glutathione peroxidase 4; GOT1: Glutamic-oxaloacetic transaminase 1; SLC1A5: Solute carrier family 1 membrane 5; GLS2: Glutaminase 2; FSP-1: Ferroptosis suppressor protein 1; ATF4: Activating transcription factor 4; AA: Arachidonic acid; ACSL4: Acyl-CoA synthetase long-chain family member 4; LPCAT3: lysophophatidylcholne acyltransferase 3; ALOXs: Lipoxygenases
Fig 3
Fig 3
The regulatory role of circRNAs in ferroptosis. Cys2: Cysteine; GSH: Reduced glutathione; SLC3A2: Solute carrier family 3 membrane 2; SLC7A11: Solute carrier family 7 membrane 11; GPX4: Glutathione peroxidase 4; ALKBH5: Alk B homologue 5; CCL5: Chemokine (C-C motif) ligand 5; EIF4A1: Eukaryotic Translation Initiation Factor 4A1; ITGB8: Integrin beta 8; GDPD5: Glycerophosphodiester phosphodiesterase domain containing 5.
See this image and copyright information in PMC

References

    1. Fuchs Y, Steller H. Programmed cell death in animal development and disease. Cell. 2011;147:742–58. - PMC - PubMed
    1. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny M V. et al. Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012;19:107–20. - PMC - PubMed
    1. Jiang N, Zhang X, Gu X, Li X, Shang L. Progress in understanding the role of lncRNA in programmed cell death. Cell Death Discov. 2021;7:30. - PMC - PubMed
    1. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Eleina M, Gleason CE. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72. - PMC - PubMed
    1. Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 2016;26:165–76. - PMC - PubMed

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