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Review
. 2022 Jun;11(2):175-183.
doi: 10.1007/s40119-022-00255-9. Epub 2022 Mar 28.

Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management

Ravi A Thakker  1 , Leonardo Salazar  2 , Deaa Abu Jazar  2 , Pooja Bhakta  2 , Bryan Baker  2 , Chandani Patel  2 , Ayman Elbadawi  3 , Mayank Agarwal  4 , Aiham Albaeni  4 , Mohammed Saleh  4 , Jonathan Esclovan  4 , Danielle El Haddad  4 , Hashim Alwash  4 , Ankur Kalra  5 , Sachin S Goel  6 , Robert Jay Widmer  7 , Khaled Chatila  4 , Wissam Khalife  4 , Afaq Motiwala  4 , Jennifer McCracken  8 , Hani Jneid  3 , Syed Gilani  4
Affiliations
Review

Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management

Ravi A Thakker et al. Cardiol Ther. 2022 Jun.

Abstract

Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.

Keywords: Acute coronary syndrome; Aspirin intolerance; Coronary artery disease.

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Figures

Fig. 1
Fig. 1
Brief overview of mechanisms of aspirin intolerance
Fig. 2
Fig. 2
Aspirin desensitization protocols
Fig. 3
Fig. 3
Proposed algorithm in managing aspirin intolerance in ischemic patients
See this image and copyright information in PMC

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