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. 2022 Jul 4;61(27):e202202614.
doi: 10.1002/anie.202202614. Epub 2022 May 5.

Multimodal Imaging-Guided Photothermal Immunotherapy Based on a Versatile NIR-II Aggregation-Induced Emission Luminogen

Dingyuan Yan  1   2 , Miao Wang  3 , Qian Wu  4 , Niu Niu  1   2 , Meng Li  1   2 , Ruixiang Song  3 , Jie Rao  3 , Miaomiao Kang  1 , Zhijun Zhang  1 , Feifan Zhou  3 , Dong Wang  1 , Ben Zhong Tang  4
Affiliations

Multimodal Imaging-Guided Photothermal Immunotherapy Based on a Versatile NIR-II Aggregation-Induced Emission Luminogen

Dingyuan Yan et al. Angew Chem Int Ed Engl. .

Abstract

Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation-induced emission, namely TPA-BT-DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near-infrared (NIR-II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death-ligand 1 (PD-L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.

Keywords: Aggregation-Induced Emission; Immunogenic Cell Death; Immunotherapy; NIR-II Emission; Photothermal Therapy.

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