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. 2023 Nov 1;40(7):567-573.
doi: 10.1097/WNP.0000000000000930. Epub 2022 Mar 25.

High-Frequency Oscillations in Tumor-Related Epilepsy

Omar Bushara  1 , Guangyu Zhou  2 , Arjun Sharma  2 , Christina Zelano  2 , Stephan U Schuele  2 , Matthew C Tate  3 , Jay R Gavvala  4 , Jessica W Templer  2
Affiliations

High-Frequency Oscillations in Tumor-Related Epilepsy

Omar Bushara et al. J Clin Neurophysiol. .

Abstract

Introduction: To define the patient characteristics, tumor characteristics, and clinical course of patients with primary brain tumors with high-frequency oscillations (HFOs) recorded on electrocorticography. Furthermore, we evaluated whether the presence of HFOs portends a greater risk of postoperative tumor-related epilepsy and whether the resection of HFO-generating tissue reduces likelihood of postoperative tumor-related epilepsy.

Methods: This was a retrospective study of 35 patients undergoing awake craniotomy for tumor resection, all of whom underwent intraoperative electrocorticography. Electrocorticography data were reviewed to assess the presence of HFOs and determine their contact locations. The data were analyzed to determine whether HFO-generating tissue was included in the resection and relationship to postoperative seizure outcome.

Results: Seventeen patients (48.5%) were found to have HFOs. Very few patients (4 of 35, 11.4%) had sharp waves. Patients with and without HFOs did not significantly differ in demographics, presentation, tumor characteristics, or tumor molecular genetics. A history of seizures prior to resection was not associated with the presence of HFOs ( P = 0.62), although when patients had seizures during the same hospitalization as the resection, HFOs were more likely to be present ( P = 0.045). Extent of HFO resection was not associated with the likelihood of postoperative seizure freedom.

Conclusions: Approximately half (48.5%) of patients undergoing resection for a primary brain tumor had HFOs. Although HFO resection was not shown to lead to improved seizure freedom, this study was limited by a small sample size, and further investigation into HFO resection and patient outcomes in this population is warranted.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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