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. 2022 Mar 1;23(3):1047-1051.
doi: 10.31557/APJCP.2022.23.3.1047.

Association of Hormonal Contraception with Meningioma Location in Indonesian Patients

Rusdy Ghazali Malueka  1 , Rahmat Andi Hartanto  2 , Nurhuda Hendra Setyawan  3 , Dyajeng Noor Firdaus Fauzi  1 , Khoironi Rachmad Damarjati  1 , Alfian Rismawan  1 , Maria Alethea Septianastiti  1 , Adiguno Suryo Wicaksono  2 , Kusumo Dananjoyo  1 , Endro Basuki  2 , Ahmad Asmedi  1 , Ery Kus Dwianingsih  4
Affiliations

Association of Hormonal Contraception with Meningioma Location in Indonesian Patients

Rusdy Ghazali Malueka et al. Asian Pac J Cancer Prev. .

Abstract

Background: Meningioma is the most common primary intracranial tumor. Previous studies have shown the possible association between hormonal contraceptive use and meningioma location. Therefore, this study aimed to analyze the association between the history of hormonal contraceptive use and the location of meningioma in the Indonesian population.

Methods: In total, 99 histologically confirmed female meningioma patients admitted to Dr. Sardjito General Hospital Yogyakarta, Indonesia, were included in this study. Data on hormonal contraception and other variables were collected from medical records. Meningioma locations were determined from brain Magnetic Resonance Imaging (MRI) or Computerized Tomography (CT) scan before surgery.

Results: Seventy-two (72.7%) patients had a history of hormonal contraceptive use. The subjects consist of 83 (83.8%) WHO grade I and 16 (16.2%) WHO grade II and III tumors. A total of 57 (57.6%) tumors were located in the spheno-orbital region. We found a significant association between hormonal contraceptive use and meningioma location in the spheno-orbital region (Odds ratio (OR) 2.573, p=0.038). This resulted in the patients in the hormonal contraception group having more visual impairment (p=0.044).

Conclusion: The use of hormonal contraception is associated with the location of meningioma in the spheno-orbital region.

Keywords: Indonesian population; hormonal contraception; meningioma; meningioma location.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

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