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. 2022 May;51(5):102366.
doi: 10.1016/j.jogoh.2022.102366. Epub 2022 Mar 25.

Impact of COVID-19 infection in pregnancy and neonates: A case control study

Camille Daclin  1 , Marie Carbonnel  2 , Manon Rossignol  1 , Hind Abbou  1 , Hela Trabelsi  1 , Aminata Cimmino  1 , Justine Delmas  1 , Anne-Sophie Rifai  1 , Lou-Andréa Coiquaud  1 , Audrey Tiberon  1 , Morgan Le Guen  3 , Jean-Marc Ayoubi  1
Affiliations

Impact of COVID-19 infection in pregnancy and neonates: A case control study

Camille Daclin et al. J Gynecol Obstet Hum Reprod. 2022 May.

Abstract

Objective: To evaluate maternal and neonatal outcomes of pregnant women who were infected by COVID-19 during pregnancy.

Study design: A Case control retrospective study was conducted in an Obstetrical Department of a west Parisian area during the first year of COVID-19 pandemic. Maternal and neonatal outcomes were compared between a group of women infected by the SARS-CoV-2 virus during pregnancy (March 2020- February 2021) and a control group of women delivering before pandemic. They were matched according to age and parity. Subgroups of SARS-CoV-2 infection occurring before vs after 37 weeks of gestations and symptomatic vs asymptomatic patients were analyzed. The rate of preterm birth, preeclampsia, placental abruption and stillbirth were compared between the year of pandemic and the year before for all deliveries.

Results: Maternal and neonatal outcomes were similar. Among the 86 pregnant women with SARS-CoV-2 infection, five were admitted to Hospital (5.8%). One was transferred in intensive care unit for respiratory distress (1.2%). All patients had favorable outcomes. Patients with symptoms had more associated comorbidities (34.5%, n = 20/58, with symptoms, vs 9,1%, n = 2/22, without symptoms, p = 0.023). No differences in preeclampsia, placenta abruption and stillbirth, but less preterm births (4.9%, n = 160/3383 vs 6.2%, n = 209/3235, p = 0.04) were observed between the year of pandemic and the year before.

Conclusion: There were few complications associated with COVID-19 infection among pregnant patients and their neonates. A low rate of associated comorbidities, a good access to healthcare services in this area and the small sample size of patients could explain these results.

Keywords: COVID-19, infection; Complications ABBREVIATIONS BMI, Body mass index; ICU, intensive care unit; NICU, neonatal intensive care unit; Neonatal outcomes; Pregnancy; SD, standard deviation; WG, weeks of gestation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig 1
Fig. 1
Flowchart.
Fig 2
Fig. 2
Color pie chart showing clinical picture and hospitalization rate.
Fig 3
Fig. 3
Histogram of preeclampsia, placental abruption and intra uterine death between 2019 and 2020 period.
See this image and copyright information in PMC

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