Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 25;50(6):777-782.
doi: 10.3724/zdxbyxb-2021-0180.

Research progress on application of microhaplotype in forensic genetics

Jing Zhou  1 , Yan Wang  1 , Enping Xu  1   2
Affiliations
Review

Research progress on application of microhaplotype in forensic genetics

Jing Zhou et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract

As a novel genetic marker, microhaplotype can be applied in the field of forensic genetics. Microhaplotype has the advantages of high polymorphism, low mutation rate, no stutter products and short amplification fragments. Microhaplotype can effectively detect mixture, and quantitatively analyze the contributors of mixture. DNA with severe fragmentation can be successfully genotyped by microhaplotype. It can be used as ancestry informative marker to effectively divide the global continental population according to genetic structure. Microhaplotype system can provide more information than traditional short tandem repeat and help to identify complex relationships. It can provide new ideas for tumor source identification, cell line identification and prenatal paternity testing. Here we review the applications of microhaplotype, intending to provide references for forensic practice.

Keywords: Ancestry inference; Biological evidence; Complex kinship testing; DNA mixture; Degraded DNA; Forensic genetics; Microhaplotype; Review.

PubMed Disclaimer

Conflict of interest statement

所有作者均声明不存在利益冲突

References

    1. PAKSTIS A J, FANG R, FURTADO M R, et al. Mini-haplotypes as lineage informative SNPs and ancestry inference SNPs[J] Eur J Hum Genet. . 2012;20(11):1148–1154. doi: 10.1038/ejhg.2012.69. - DOI - PMC - PubMed
    1. KIDD K K, PAKSTIS A J, SPEED W C, et al. Microhaplotype loci are a powerful new type of forensic marker[J/OL] Forensic Sci Int-Genet Supplement Ser. . 2013;4(1):e123–e124. doi: 10.1016/j.fsigss.2013.10.063. - DOI
    1. OLDONI F, PODINI D. Forensic molecular biomarkers for mixture analysis[J] Forensic Sci Int-Genet. . 2019;41:107–119. doi: 10.1016/j.fsigen.2019.04.003. - DOI - PubMed
    1. JUNG J Y, PARK J H, OH Y L, et al. Forensic genetic study of 29 Y-STRs in Korean population[J] Legal Med. . 2016;23:17–20. doi: 10.1016/j.legalmed.2016.09.001. - DOI - PubMed
    1. VAN DER GAAG K J, DE LEEUW R H, HOOGENBOOM J, et al. Massively parallel sequencing of short tandem repeats——population data and mixture analysis results for the PowerSeq TM system[J] . Forensic Sci Int-Genet. . 2016;24:86–96. doi: 10.1016/j.fsigen.2016.05.016. - DOI - PubMed