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Case Reports
. 2023 Mar 1;42(2):151-154.
doi: 10.1097/PGP.0000000000000874. Epub 2022 May 20.

Metastatic Uterine Leiomyosarcoma With Rhabdomyosarcomatous Heterologous Differentiation

Baris Boyraz, Tasos Gogakos, Kevin A Raskin, Gunnlaugur Petur Nielsen
Case Reports

Metastatic Uterine Leiomyosarcoma With Rhabdomyosarcomatous Heterologous Differentiation

Baris Boyraz et al. Int J Gynecol Pathol. .

Abstract

Heterologous differentiation has only been previously reported twice in metastatic uterine leiomyosarcomas. We report herein the first case of metastatic uterine leiomyosarcoma with rhabdomyosarcomatous differentiation. A 67-yr-old woman presented with femur, abductor magnus, and lymph node metastases 9 yr after the primary diagnosis. The metastatic sites showed rhabdomyosarcomatous morphologic features, and immunohistochemical studies confirmed skeletal muscle differentiation. Molecular testing revealed the same loss-of-function TP53 mutation in the uterine leiomyosarcoma and metastatic sites supporting heterologous differentiation of the primary tumor. Our case highlights the morphologic shifts metastatic tumors may manifest and the potential diagnostic problems that may arise.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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