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. 2022 Mar 29;15(727):eabo1118.
doi: 10.1126/scisignal.abo1118. Epub 2022 Mar 29.

Tuning the signal: ATP-sensitive K+ channels direct blood flow to cerebral capillaries

William F Jackson  1
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Tuning the signal: ATP-sensitive K+ channels direct blood flow to cerebral capillaries

William F Jackson. Sci Signal. .

Abstract

Cerebral blood flow must be exquisitely regulated to match the metabolic demands of neurons. In this issue of Science Signaling, Sancho et al. characterize functional ATP-sensitive K+ (KATP) channels in cerebral capillary endothelial cells and pericytes that can be activated by adenosine signaling, thereby leading to increases in capillary blood flow.

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