Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 8:9:798523.
doi: 10.3389/fsurg.2022.798523. eCollection 2022.

Current Opinion and Practice on Peritoneal Carcinomatosis Management: The North African Perspective

Amine Souadka  1 , Hajar Essangri  1 , Amin Makni  2 , Mourad Abid  3 , Mouna Ayadi  4 , Feriel Ksantini  4 , Zakia Kordjani  3 , Yousri Ballah  3 , Jemila Bouka  5 , Amine Benkabbou  1 , Mohammed Anass Majbar  1 , Basma El Khannoussi  6 , Raouf Mohsine  1 , Saber Boutayeb  7 , Martin Hubner  8
Affiliations

Current Opinion and Practice on Peritoneal Carcinomatosis Management: The North African Perspective

Amine Souadka et al. Front Surg. .

Abstract

Background: The status of peritoneal surface malignancy (PSM) management in North Africa is undetermined. The aim of this study was to assess and compare current practice and knowledge regarding PSM and examine satisfaction with available treatment options and need for alternative therapies in North Africa.

Methods: This is a qualitative study involving specialists participating in PSM management in North Africa. The survey analyzed demographic characteristics and current knowledge and opinions regarding PSM management in different institutions. We also looked at goals and priorities, satisfaction with treatment modalities and heated intraperitoneal chemotherapy (HIPEC) usefulness according to specialty, country, years of experience, and activity sector.

Results: One-hundred and three participants responded to the survey (response rate of 57%), including oncologists and surgeons. 59.2% of respondents had more than 10 years experience and 45.6% treated 20-50 PSM cases annually. Participants satisfaction with PSM treatment modalities was mild for gastric cancer (3/10 [IQR 2-3]) and moderate for colorectal (5/10 [IQR 3-5]), ovarian (5/10 [IQR 3-5]), and pseudomyxoma peritonei (5/10 [IQR 3-5]) type of malignancies. Good quality of life and symptom relief were rated as main priorities for treatment and the need for new treatment modalities was rated 9/10 [IQR 8-9]. The perceived usefulness of systemic chemotherapy in first intention was described as high by 42.7 and 39.8% of respondents for PSM of colorectal and gastric origins, while HIPEC was described as highly useful for ovarian (49.5%) and PMP (73.8) malignancies.

Conclusions: The management of PSM in the North African region has distinct differences in knowledge, treatments availability and priorities. Disparities are also noted according to specialty, country, years of expertise, and activity sector. The creation of referral structures and PSM networks could be a step forward to standardized PSM management in the region.

Keywords: HIPEC; LMIC; North Africa; PIPAC; peritoneal carcinomatosis; surveys and questionnaires.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Satisfaction with treatment modalities for PSM.
Figure 2
Figure 2
Main priorities in the treatment of peritoneal carcinomatosis.
See this image and copyright information in PMC

References

    1. Eng OS, Turaga KK. Cytoreduction and hyperthermic intraperitoneal chemotherapy in metastatic colorectal cancer. J Surg Oncol. (2019) 119:613–5. 10.1002/jso.25438 - DOI - PubMed
    1. Glehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J. Clin. Oncol. (2004) 22:3284–92. 10.1200/jco.2004.10.012 - DOI - PubMed
    1. Goéré D, Souadka A, Faron M, Cloutier AS, Viana B, Honoré C, et al. Extent of colorectal peritoneal carcinomatosis: attempt to define a threshold above which HIPEC does not offer survival benefit: a comparative study. Ann Surg Oncol. (2015) 22:2958–64. 10.1245/s10434-015-4387-5 - DOI - PubMed
    1. Manzanedo I, Pereira F, Rihuete Caro C, Pérez-Viejo E, Serrano Á, Gutiérrez Calvo A, et al. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for gastric cancer with peritoneal carcinomatosis: multicenter study of spanish group of peritoneal oncologic surgery (GECOP). Ann Surg Oncol. (2019) 26:2615–21. 10.1245/s10434-019-07450-4 - DOI - PubMed
    1. Honoré C, Goéré D, Messager M, Souadka A, Dumont F, Piessen G, et al. Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. Eur J Surg Oncol. (2013) 39:235–41. 10.1016/j.ejso.2012.12.013 - DOI - PubMed