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Case Reports
. 2022 Feb 7;15(1):86-90.
doi: 10.1159/000521122. eCollection 2022 Jan-Apr.

Genetic Analysis of a Family with Multiple Incidences of Prostate Cancer

Ninghan Feng  1 , Fengping Liu  2 , Xinyu Xu  1 , Yang Wang  1 , Qingsong Sheng  3 , Kuichun Zhu  3
Affiliations
Case Reports

Genetic Analysis of a Family with Multiple Incidences of Prostate Cancer

Ninghan Feng et al. Case Rep Oncol. .

Abstract

A family with multiple members diagnosed with prostate cancer was identified, and genetic variants were analyzed. Three brothers were diagnosed with prostate cancer. Germline variants in BRCA1, BRCA2, TINF2, and CD19 were found through next-generation DNA sequencing using a hereditary cancer panel. The BRCA1 G275D variant was present in patients, but absent in the healthy member. An ELAC2 variant was found in 1 patient. Several mutations were predicted to be deleterious by a set of computation programs. Multiple gene mutations might contribute to the overall predisposition to prostate cancer in the family. Even in cases with potentially deleterious variants in BRCA1 or BRCA2, there could be diverse clinical manifestations.

Keywords: Genetic; Germline; Mutation; Predisposition; Prostate cancer.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Family pedigree. *This subject was out of contact.
See this image and copyright information in PMC

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