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. 2022 Mar 28;12(1):5296.
doi: 10.1038/s41598-022-09375-7.

Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda

Ester Lilian Acen  1 , Irene Andia Biraro  2   3 , Mudarshiru Bbuye  4 , David Patrick Kateete  5 , Moses L Joloba  5 , William Worodria  6
Affiliations

Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda

Ester Lilian Acen et al. Sci Rep. .

Abstract

An estimated one billion people globally live with hypovitaminosis D. Studies have indicated that vitamin D deficiency is a risk factor for active tuberculosis (TB) disease. The aim of this study was to determine the association between vitamin D deficiency and TB status among patients with active TB, latent TB infection (LTBI) and those without TB infection. In a cross-sectional study of active TB patients, LTBI, QuantiFERON GOLD testpositive and (QFN+TST+) household contact and controls QuantiFERON GOLD testnegative (QFN-TST-) samples vitamin D levels were compared. Vitamin D status was determined by measurement of total vitamin D levels with 56 samples of active TB patients, 17 with LTBI, and 22 without TB infection using electrochemiluminescence. The median interquartile range (IQR) age of the study participants was 28 (20-35) years, and the majority (63%) were females. The median (IQR) vitamin D levels were 18 ng/ml (14-24). All groups had vitamin D hypovitaminosis with significantly lower levels among active TB patients (17 ng/ml, 13, 2) than among LTBI individuals (23 ng/ml 16-29) and those without TB infection (22 ng/ml, 17-28).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Box plot of vitamin D levels in participants with ATB, LTBI, and without TB infection. The boxes represent medians, and the upper and lower ends of the box represent the 75th and 25th percentiles, while the whiskers are the 5th and 95th percentiles with significance at < 0.05. Low vitamin D levels were observed in all three study groups with the lowest levels found in active TB patients (< 20 n/ml). The figure was generated using STATA version12, https://www.stata.com by M.B.
Figure 2
Figure 2
Vitamin D levels and age of active TB patients, LTBI individuals, and those without TB. The boxes represent medians, and the upper and lower ends of the box represent the 75th and 25th percentiles, respectively, while the whiskers are the 5th and 95th percentiles for significance at < 0.05. All ages show deficient and insufficient median levels with no optimal median levels (≥ 30 ng/ml) recorded. The figure was generated using STATA version12, https://www.stata.com by M.B.
See this image and copyright information in PMC

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