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. 2022 Mar;172(5):579-582.
doi: 10.1007/s10517-022-05440-3. Epub 2022 Mar 30.

Metabolism of a New Dipeptide Neuroprotector in Rats

G B Kolyvanov  1 , P O Bochkov  1 , A A Litvin  2 , R V Shevchenko  1 , A L Podol'ko  1 , O Yu Kravtsova  1 , K N Kolyasnikova  1 , V P Zherdev  1
Affiliations

Metabolism of a New Dipeptide Neuroprotector in Rats

G B Kolyvanov et al. Bull Exp Biol Med. 2022 Mar.

Abstract

Metabolism of a new neuroprotector GZK-111 (N-phenylacetylglycyl-L-proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis of the ester bond by esterases followed by degradation of the resulting metabolite, as well as reactions leading to the formation of phenylacetic acid and cycloprolylglycine that exhibits neuropsychotropic activity.

Keywords: GZK-111; HPLC-mass spectrometry; metabolism; neuroprotector.

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References

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