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. 2022 May;19(5):e202200053.
doi: 10.1002/cbdv.202200053. Epub 2022 Apr 12.

Protective Effects of Shorea roxburghii Phenolic Extract on Nephrotoxicity Induced by Cyclophosphamide: Impact on Oxidative Stress, Biochemical and Histopathological Alterations

Jun Hu  1 , Changjun Tong  1 , Jiajun Zhou  1 , Chaoqing Gao  1 , Opeyemi Joshua Olatunji  2
Affiliations

Protective Effects of Shorea roxburghii Phenolic Extract on Nephrotoxicity Induced by Cyclophosphamide: Impact on Oxidative Stress, Biochemical and Histopathological Alterations

Jun Hu et al. Chem Biodivers. 2022 May.

Abstract

Cyclophosphamide (CTX) is one of the most commonly used alkylating agents for the treatment of various cancers; however, CTX-induced nephrotoxicity is one of the most prevailing side effects of the drug. Shorea roxburghii is a plant with diverse bioactivities including antioxidant, anti-inflammatory and renoprotective effects. This study investigated the nephroprotective effect of Shorea roxburghii phenolic extract (SRPF) against CTX-induced nephrotoxicity in rats. The rats were treated with SRPF (100 and 400 mg/kg) for 5 weeks and were concomitantly administered with CTX. The results indicated that treatment with SRPF significantly decreased serum creatinine, blood urea nitrogen (BUN), uric acid as well as renal MDA, IL-6, TNF-α, IL-1β, NF-kB and caspase-3 levels. Furthermore, SRPF augmented the activities of renal SOD, CAT, GSH and GPx. SRPF also improved renal histopathological damages caused by CTX administration. In conclusion, these results suggested that SRPF showed substantial protective effects against CTX-mediated renal toxicity via its antioxidant and anti-inflammatory effects.

Keywords: Shorea roxburghii; cyclophosphamide; nephrotoxicity; oxidative stress; polyphenols.

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