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. 2022 Dec;54(1):886-892.
doi: 10.1080/07853890.2022.2057582.

Factors associated with poor compliance amongst hospitalized, predominantly adolescent pediatric Crohn's disease patients

Nathaniel A Cohen  1 , Dejan M Micic  1 , Atsushi Sakuraba  1
Affiliations

Factors associated with poor compliance amongst hospitalized, predominantly adolescent pediatric Crohn's disease patients

Nathaniel A Cohen et al. Ann Med. 2022 Dec.

Abstract

Background: Compliance with medical treatment is vital for the control of inflammatory bowel disease (IBD) and prevention of disease complications and is an issue in paediatric patients. We explored patient-related factors associated with non-compliance in a large database of predominantly adolescent, hospitalized paediatric Crohn's disease (CD) patients.

Patients/materials and methods: We analyzed data from the Kid's Inpatient Database (KID) the largest publicly available all-payer paediatric inpatient care database in the United States. All available paediatric CD patients non-electively admitted in 2016 were included. CD patients were extracted using the standard international classification of diseases (ICD) 10 codes. Data suggesting non-compliance, comorbidities and surgical procedures related to CD were similarly extracted.

Results: 2439 paediatric CD patients with non-elective admission were included in the analysis. 2 280 patients (94%) were adolescents. Of the total cohort, 113 patients (4.6%) had a diagnosis of non-compliance. In univariate analyses, smoking (15.9 vs. 5.5%, p < .001), cannabis use (5.3 vs 1.5%, p = .009), and a diagnosis of depression (19.5 vs. 9%, p = .001) or schizoaffective disorder (5.3 vs 0.3%, p < .001) were associated with non-compliance. Multivariable analysis revealed that schizoaffective disorder (odds ratio (OR) 11.6, 95% CI 3.6-37.2), depression (OR 1.9, 95%CI 1.2-3.2) and smoking (OR 2.2, 95%CI 1.25-4) were independently associated with non-compliance.

Conclusions: In this study, mental health disorders and smoking were independently associated with non-compliance to medication in predominantly adolescent, hospitalized paediatric CD patients. A multidisciplinary approach involving paediatric gastroenterologists, psychiatrists and addiction specialists are needed to treat the underlying causes and improve adherence in these patients.KEY MESSAGESMental health disorders and smoking are independent risk factors for medication non-compliance amongst adolescent, paediatric CD patients.A multidisciplinary approach is required to treat underlying causes and improve adherence in paediatric IBD patients.

Keywords: Compliance; Crohn’s disease; inflammatory bowel disease; paediatric gastroenterology.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Flow chart detailing the study design.
Figure 2.
Figure 2.
Forest plot showing the odds ratios of various factors associated with a diagnosis of non-compliance in hospitalized paediatric patients. OR: odds ratio; CI: confidence interval.
See this image and copyright information in PMC

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