Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Linzy Houchen-Wolloff^{1

2}, Krisnah Poinasamy³, Kate Holmes⁴, Maryrose Tarpey⁵, Claire Hastie⁶, Kelly Raihani⁶, Natalie Rogers⁶, Nikki Smith⁶, Dawn Adams⁷, Paul Burgess⁷, Jean Clark⁷, Clare Cranage⁷, Mahadev Desai⁷, Nicola Geary⁷, Rhyan Gill⁷, Jitendra Mangwani⁸, Lily Staunton⁷, Colin Berry⁹, Charlotte E Bolton¹⁰, Trudie Chalder¹¹, James Chalmers¹², Anthony De Soyza¹³, Omer Elneima^{1

2}, John Geddes¹⁴, Simon Heller¹⁵, Ling-Pei Ho^{16

17}, Joseph Jacob^{18

19}, Hamish McAuley^{1

2}, Aarti Parmar^{1

2}, Jennifer K Quint²⁰, Betty Raman²¹, Matthew Rowland²², Amisha Singapuri², Sally J Singh^{1

2}, David Thomas²³, Mark R Toshner^{24

25}, Louise V Wain^{2

26}, Alex Robert Horsley²⁷, Michael Marks²⁸, Christopher E Brightling^{1

2}, Rachael A Evans^{29

2}

Affiliations

¹ Respiratory Sciences, University of Leicester, Leicester, UK.
² NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
³ Research and Innovation Advocacy, Asthma & Lung UK, London, UK.
⁴ Office for Clinical Research Infrastructure (NOCRI), National Institute for Health Research, London, UK.
⁵ James Lind Alliance, University of Southampton, Southampton, UK.
⁶ Long Covid Support, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
⁷ Patient and Public Involvement Group, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
⁸ Leicester Orthopaedic Research Network, University Hospitals of Leicester NHS Trust, Leicester, UK.
⁹ British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
¹⁰ Respiratory Medicine, NIHR Nottingham Biomedical Research Centre Respiratory Theme, University of Nottingham, Nottingham, UK.
¹¹ Pyschological Medicine, King's College London, London, UK.
¹² Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
¹³ Lung Biology and Transplantation Group, Newcastle University, Newcastle upon Tyne, UK.
¹⁴ Department of Psychiatry, University of Oxford, Oxford, UK.
¹⁵ Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
¹⁶ Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
¹⁷ Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK.
¹⁸ Centre for Medical Imaging and Computing, University College London, London, UK.
¹⁹ Department of Respiratory Medicine, University College London, London, UK.
²⁰ Respiratory Epidemiology, Occupational Medicine and Public Health, Imperial College London, London, UK.
²¹ Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
²² Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
²³ Department of Immunology and Inflammation, Imperial College London, London, UK.
²⁴ Pulmonary Vascular Disease Unit, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
²⁵ School of Clinical Medicine, University of Cambridge, Cambridge, UK.
²⁶ Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
²⁷ Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, UK.
²⁸ Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
²⁹ Respiratory Sciences, University of Leicester, Leicester, UK re66@leicester.ac.uk.

PMID: 35354642
PMCID: PMC9209667
DOI: 10.1136/thoraxjnl-2021-218582

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Linzy Houchen-Wolloff et al. Thorax. 2022 Jul.

. 2022 Jul;77(7):717-720.

doi: 10.1136/thoraxjnl-2021-218582. Epub 2022 Mar 30.

Authors

Affiliations

¹ Respiratory Sciences, University of Leicester, Leicester, UK.
² NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
³ Research and Innovation Advocacy, Asthma & Lung UK, London, UK.
⁴ Office for Clinical Research Infrastructure (NOCRI), National Institute for Health Research, London, UK.
⁵ James Lind Alliance, University of Southampton, Southampton, UK.
⁶ Long Covid Support, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
⁷ Patient and Public Involvement Group, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
⁸ Leicester Orthopaedic Research Network, University Hospitals of Leicester NHS Trust, Leicester, UK.
⁹ British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
¹⁰ Respiratory Medicine, NIHR Nottingham Biomedical Research Centre Respiratory Theme, University of Nottingham, Nottingham, UK.
¹¹ Pyschological Medicine, King's College London, London, UK.
¹² Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
¹³ Lung Biology and Transplantation Group, Newcastle University, Newcastle upon Tyne, UK.
¹⁴ Department of Psychiatry, University of Oxford, Oxford, UK.
¹⁵ Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
¹⁶ Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
¹⁷ Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK.
¹⁸ Centre for Medical Imaging and Computing, University College London, London, UK.
¹⁹ Department of Respiratory Medicine, University College London, London, UK.
²⁰ Respiratory Epidemiology, Occupational Medicine and Public Health, Imperial College London, London, UK.
²¹ Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
²² Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
²³ Department of Immunology and Inflammation, Imperial College London, London, UK.
²⁴ Pulmonary Vascular Disease Unit, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
²⁵ School of Clinical Medicine, University of Cambridge, Cambridge, UK.
²⁶ Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
²⁷ Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, UK.
²⁸ Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
²⁹ Respiratory Sciences, University of Leicester, Leicester, UK re66@leicester.ac.uk.

PMID: 35354642
PMCID: PMC9209667
DOI: 10.1136/thoraxjnl-2021-218582

Abstract

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.

Keywords: COVID-19.

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Conflict of interest statement

Competing interests: LH-W reports grants from the NIHR and ARC, outside the submitted work. TC reports grants from UK NIHR, UKRI and Guy’s and St Thomas’ Charity. She has delivered workshops on persistent physical symptoms in the context of long-term conditions, during the conduct of the study for which she has received payment. She is the author of self-help books on fatigue. She is a member of the NICE expert advisory panel for Covid19 Rapid Guidelines.JJ reports fees from Boehringer Ingelheim, Roche, NHSX and GlaxoSmithKline unrelated to the submitted work. JJ is supported by Wellcome Trust Clinical Research Career Development Fellowship 209,553/Z/17/Z and the NIHR UCLH Biomedical Research Centre, UK.SH reports consultancy for Eli Lily, NovoNordisk and Zealand Pharma for which his institution has received payment. He serves on a speaker panel for NovoNordisk for which he and his institution receive payment. MR is currently employed by Roches on a one year senior academic/ industry fellowship. JDC reports grants and personal fees from AstraZeneca, Boehringer-Ingelheim, GlaxoSmithKline, Novartis, and Insmed, personal fees from Chiesi, Zambon, Janssen, and Grifols, and grants from Gilead Sciences, outside the submitted work. AH reports personal fees from Vertex Pharmaceuticals, Mylan Healthcare, and the Cystic Fibrosis Foundation, and grants from JP Moulton Trust and NIHR, outside the submitted work. MT reports personal fees from Merck Sharp & Dohme and GlaxoSmithKline, and grants and personal fees from Bayer and Actelion, during the conduct of the study. LVW reports grants from GlaxoSmithKline and Orion, outside the submitted work. ADS reports grants and personal fees from AstraZeneca, Bayer, Boehringer, Chiesi, Forest Laboratories, GlaxoSmithKline, Grifols, Insmed, MedImmune, Novartis, Pfizer, and 30T, outside the submitted work. RAE reports grants from GlaxoSmithKline during the conduct of the study; and grants from the National Institute for Health Research (NIHR) and personal fees from GlaxoSmithKline, AstraZeneca, and Chiesi, outside the submitted work. All other authors declare no competing interests.

Figures

**Figure 1**
Methodology of the research prioritisation process and input at all stages from key stakeholders. BRC PPI, Biomedical Research Centre Patient and Public Involvement; PHOSP, post-hospitalisation COVID-19.

See this image and copyright information in PMC

References

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1. World Health Organisation . A clinical case definition of post COVID-19 condition by a Delphi consensus, 2021. Available: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_cond... [Accessed 03 Dec 2021].
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1. Evans RA, Leavy OC, Richardson M, on behalf of the PHOSP-COVID Collaborative Group . Clinical characteristics with inflammation profiling of Long-COVID and association with one-year recovery following hospitalisation in the UK: a prospective observational study. medRxiv 2021. 10.1101/2021.12.13.21267471 - DOI - PMC - PubMed

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Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Affiliations

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical