Making innate sense of mRNA vaccine adjuvanticity

Kouji Kobiyama^{1

2

3}, Ken J Ishii^{4

5

6}

Affiliations

¹ Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
² International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
³ Center for Vaccine Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
⁴ Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.
⁵ International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.
⁶ Center for Vaccine Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. kenishii@ims.u-tokyo.ac.jp.

Comment

Kouji Kobiyama et al. Nat Immunol. 2022 Apr.

. 2022 Apr;23(4):474-476.

doi: 10.1038/s41590-022-01168-4.

Kouji Kobiyama^{1

2

3}, Ken J Ishii^{4

5

6}

¹ Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
² International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
³ Center for Vaccine Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
⁴ Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.
⁵ International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.
⁶ Center for Vaccine Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. kenishii@ims.u-tokyo.ac.jp.

No abstract available

Comment on

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine.
Li C, Lee A, Grigoryan L, Arunachalam PS, Scott MKD, Trisal M, Wimmers F, Sanyal M, Weidenbacher PA, Feng Y, Adamska JZ, Valore E, Wang Y, Verma R, Reis N, Dunham D, O'Hara R, Park H, Luo W, Gitlin AD, Kim P, Khatri P, Nadeau KC, Pulendran B. Li C, et al. Nat Immunol. 2022 Apr;23(4):543-555. doi: 10.1038/s41590-022-01163-9. Epub 2022 Mar 14. Nat Immunol. 2022. PMID: 35288714 Free PMC article.
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. Tahtinen S, et al. Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24. Nat Immunol. 2022. PMID: 35332327

1. Li, C. et al. Nat Immunol. https://doi.org/10.1038/s41590-022-01163-9 (2022).
1. Tahtinen, S. et al. Nat Immunol. https://doi.org/10.1038/s41590-022-01160-y (2022).
1. Desmet, C. J. & Ishii, K. J. Nat. Rev. Immunol. 12, 479–491 (2012). - DOI
1. de Oliveira Mann, C. C. & Hornung, V. Eur. J. Immunol. 51, 1897–1910 (2021). - DOI
1. Kariko, K., Buckstein, M., Ni, H. & Weissman, D. Immunity 23, 165–175 (2005). - DOI