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. 2022 Mar 30;204(4):230.
doi: 10.1007/s00203-022-02853-6.

The effects of antidepressants fluoxetine, sertraline, and amitriptyline on the development of antibiotic resistance in Acinetobacter baumannii

Suna Sibel Gurpinar  1 , Didem Kart  2 , Mujde Eryilmaz  3
Affiliations

The effects of antidepressants fluoxetine, sertraline, and amitriptyline on the development of antibiotic resistance in Acinetobacter baumannii

Suna Sibel Gurpinar et al. Arch Microbiol. .

Abstract

This study investigates the effects of antidepressants fluoxetine, sertraline, and amitriptyline on the development of antibiotic resistance in clinical Acinetobacter baumannii isolates. The isolates were exposed to fluoxetine, sertraline, and amitriptyline for 30 days, respectively. The bacteria that developed resistance to gentamicin, imipenem, colistin, and ciprofloxacin were isolated and expression levels of some antibiotic-resistance genes were determined by quantitative reverse-transcriptase PCR. Before and after the exposure, minimum inhibitory concentration (MIC) values of the bacteria were determined by the microdilution method. The statistical analysis was performed using Student's t test. A time-dependent increase was observed in the number of bacteria that developed resistance and increased the MIC value. After exposure to fluoxetine and sertraline, decreases were observed for efflux and outer membrane porin genes in isolates that developed colistin resistance, and increases were observed in isolates that developed ciprofloxacin resistance. These observations suggest that these antidepressants have similar effects on the development of resistance. While the exposure to fluoxetine did not result in the development of resistance to imipenem, it was observed after exposure to sertraline and amitriptyline, and a common decrease in ompA gene expression was determined in these isolates. To our knowledge, the comparative effects of selected antidepressants on the development of antibiotic resistance in A. baumannii are reported and presented in the literature here for the first time.

Keywords: Acinetobacter baumannii; Antibiotic resistance; Antidepressant; Efflux pumps genes; Outer membrane porin genes.

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References

    1. Altamura AC, Moro AR, Percudani M (1994) Clinical pharmacokinetics of fluoxetine. Clin Pharmacokinet 26(3):201–214. https://doi.org/10.2165/00003088-199426030-00004 - DOI - PubMed
    1. Alvano SA, Zieher LM (2020) An updated classification of antidepressants: a proposal to simplify treatment. Pers Med Psychiatry. https://doi.org/10.1016/j.pmip.2019.04.002 - DOI
    1. Ayaz M, Subhan F, Ahmed J, Khan AU, Ullah F, Ullah I, Ali G, Syed NH, Hussain S (2015) Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance. J Biol Res-Thessalon 22(1):4. https://doi.org/10.1186/s40709-015-0028-1 - DOI - PubMed - PMC
    1. Brooks BW, Foran CM, Richards SM et al (2003) Aquatic ecotoxicology of fluoxetine. Toxicol Lett 142:169–183. https://doi.org/10.1016/s0378-4274(03)00066-3 - DOI - PubMed
    1. Catel-Ferreira M, Marti S, Guillon L et al (2016) The outer membrane porin OmpW of Acinetobacter baumannii is involved in iron uptake and colistin binding. FEBS Lett 590:224–231. https://doi.org/10.1002/1873-3468.12050 - DOI - PubMed

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