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. 2022 May;167(5):1307-1310.
doi: 10.1007/s00705-022-05424-8. Epub 2022 Mar 31.

Human-stool-associated tusavirus (Parvoviridae) in domestic goats and sheep

Gábor Reuter  1 , Péter Pankovics  2 , Zoltán László  2 , Gábor Gáspár  2 , Alvin Hui  3 , Eric Delwart  3   4 , Ákos Boros  2
Affiliations

Human-stool-associated tusavirus (Parvoviridae) in domestic goats and sheep

Gábor Reuter et al. Arch Virol. 2022 May.

Abstract

In this study, genetic counterparts of the human-stool-associated tusavirus (subfamily Parvovirinae, family Parvoviridae) with >97% and 95-100% amino acid sequence identity in the parvoviral NS1 and VP1 protein were identified in faecal specimens from domestic goats (Capra hircus) and sheep (Ovis aries) in Hungary. Eleven (17.8%) of the 62 faecal specimens from goats and 12 (25.5%) of the 47 from sheep both from less than 12 months old animals were positive for tusavirus DNA by PCR, while none of the specimens collected from cattle and swine were positive. Thus, it cannot be ruled out that tusavirus infection in humans is of zoonotic origin.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
A phylogenetic tree based on a MUSCLE alignment [11] of the VP1 capsid amino acid sequences of representative members of the subfamily Parvovirinae and the tusavirus strains from this study (in bold). The tree was generated from the alignment using the maximum-likelihood method and the general reverse transcriptase ???? + Freq. model with 1000 bootstrap replicates, which was selected based on the results of a best-model search in MEGA ver. 10.2.1 [12]. Bootstrap values less than 50 were omitted from the tree. The host species of the studied viruses (from goat and ovine) and the known tusavirus from humans are indicated by silhouettes.
See this image and copyright information in PMC

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