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. 2022 Sep;42(9):2801-2809.
doi: 10.1007/s10792-022-02270-0. Epub 2022 Mar 30.

Corneal hysteresis and intraocular pressure are altered in silicone-hydrogel soft contact lenses wearers

María Concepción Marcellán  1 , Laura Remón  1 , Francisco J Ávila  2
Affiliations

Corneal hysteresis and intraocular pressure are altered in silicone-hydrogel soft contact lenses wearers

María Concepción Marcellán et al. Int Ophthalmol. 2022 Sep.

Abstract

Purpose: The aim of this work is to determinate the effects in the physical parameters in terms of intraocular pressure (IOP) and central corneal thickness (CCT) and corneal biomechanics in terms of corneal resistance factor (CRF) and corneal hysteresis (CH) of wearing silicone-hydrogel soft contact lenses (SiH-CLs) in young adult subjects during a short-term follow-up.

Methods: 40 eyes of 20 healthy patients with a mean age of 22.87 ± 4.14 were involved in this study. Subjects with corneal diseases, dry eye, irregular astigmatism or who have been previous contact lens wearers were excluded. The ocular response analyzer (Reichert Ophthalmic Instruments) was used to measure CH, CRF and IOP and Scheimpflug imaging (the GALILEI™ Dual Scheimpflug camera analyzer, Ziemer) was used to measure CCT before and 10 days (Group 1) and 20 days (Group 2) after wearing the SiH-CLs.

Results: IOP was significantly decreased 10 days after using the SiH-CLs (p = 0.009). Within the 20 days' period, Group 2 revealed an even more pronounced decrease in IOP (p = 0.003) while CH increased significantly (p = 0.04). CCT and CRF did not show a significant change during the period of SiH-CLs use. Our finding allowed obtaining an empirical expression that relates IOP, CCT, CRF and CH within a biomechanical compensation experimental model.

Conclusions: Corneal biomechanical parameters and physical properties of the cornea may be altered due to SiH-CLs use. Our findings could have an impact on the management of glaucoma progression and ocular hypertension.

Keywords: Corneal biomechanics; Glaucoma; Intraocular pressure; Soft contact lenses.

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Conflict of interest statement

Authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Box diagrams of IOP (a), CCT (b), CH (c) and CRF (d) values comparing control measurements with each temporal group. For each box, the median (central line inside each box), the Q1 and Q4 quartiles (lower and higher borders of each box, respectively) and maximum and minimum values (whiskers) are shown. (*p < 0.05; **p < 0.005)
Fig. 2
Fig. 2
Mean variation PIO (a), CCT (b), CH (c) and CRF (d) values of the two studied temporal groups (10 and 20 days). (*p < 0.05)
Fig. 3
Fig. 3
Correlation and best mathematical fitting between physical and biomechanical parameters. The correlation results are shown within the shaded boxes
See this image and copyright information in PMC

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