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. 2022 Jun;145(6):649-657.
doi: 10.1111/ane.13617. Epub 2022 Mar 31.

Pathophysiology of transient neurological deficit in patients with chronic subdural hematoma: A systematic review

Jurre Blaauw  1   2 , Josje M van Zundert  1 , Heleen M den Hertog  3 , Niels A van der Gaag  4   5 , Korné Jellema  6 , Ruben Dammers  7 , Rob J M Groen  8 , Hester F Lingsma  2 , Joukje van der Naalt  1 , Bram Jacobs  1
Affiliations

Pathophysiology of transient neurological deficit in patients with chronic subdural hematoma: A systematic review

Jurre Blaauw et al. Acta Neurol Scand. 2022 Jun.

Abstract

Patients with chronic subdural hematoma (CSDH) can have transient neurological deficits deficit (TND) mimicking transient ischemic attacks. The prevalence of TNDs in CSDH varies between 1%-24%, depending on TND definition. Despite this high prevalence the pathophysiology of TND in CSDH is not clear in many cases. In this systematic review, we aim to unravel the responsible mechanism. Pubmed and Embase were searched for all articles concerning the pathophysiology of TND as a presenting symptom in patients with CSDH. There were no publication date restrictions for the articles in the search. Two reviewers independently selected studies for inclusion and subsequently extracted the necessary data. Out of 316 identified references, 15 met the inclusion criteria. Several articles mentioned multiple pathophysiological mechanisms. One of the proposed etiologies of TND was epileptic activity, stated by three articles. In contrast, three different studies stated that seizures are unlikely to cause TND. Five papers suggested that obstruction of blood flow, caused by the hematoma or subsequent swelling, might be the cause. Six articles made no definite statement on the responsible pathophysiological mechanism of TND. Different mechanisms have been proposed to be the cause of TNDs in patients with CSDH. Based on this review, the exact pathophysiology of TND remains unclear. We suggest that future studies on this topic should incorporate MRI of the brain (with diffusion-weighted imaging) and EEG, to provide better insight into TND pathophysiology. The knowledge resulting from future studies might contribute to better understanding of TND and optimal treatment in CSDH.

Keywords: chronic subdural hematoma; pathophysiology; systematic review; transient neurological deficits.

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References

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