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Clinical Trial
. 1986 Nov;143(11):1464-6.
doi: 10.1176/ajp.143.11.1464.

Withdrawal syndrome with gradual tapering of alprazolam

T A Mellman, T W Uhde
Clinical Trial

Withdrawal syndrome with gradual tapering of alprazolam

T A Mellman et al. Am J Psychiatry. 1986 Nov.

Abstract

The clinical and biological correlates of gradual alprazolam withdrawal were investigated in 10 patients in a double-blind, placebo-controlled trial. During gradual alprazolam withdrawal, anxiety and plasma cortisol levels were higher than during a postwithdrawal medication-free period.

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