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Case Reports
. 2022 Mar 9:9:840795.
doi: 10.3389/fmed.2022.840795. eCollection 2022.

Situs Inversus Totalis on 18F-FDG PET/CT: A Case Report and a Literature Review

Xu-Sheng Liu  1 , Rui-Min Wu  1 , Hua-Bing Wan  1 , Yi-Jia Chen  1 , Fan Tan  1 , Dao-Bing Zeng  1 , Yi Yang  1 , Zhi-Jun Pei  1
Affiliations
Case Reports

Situs Inversus Totalis on 18F-FDG PET/CT: A Case Report and a Literature Review

Xu-Sheng Liu et al. Front Med (Lausanne). .

Abstract

A 62-year-old female patient with pathologically confirmed left lung small cell neuroendocrine carcinoma. The patient was referred to our positron emission tomography (PET)/CT center to look for possible metastatic diseases. After fasting for 8 h, the fasting blood glucose level of the patient was 7.1 mmol/L. The patient was intravenously injected with a 6.42 mCi (238 MBq) 18F-fluorodeoxyglucose (FDG) imaging agent. After the patient rested for 1 h, we scanned the patient with SIEMENS Biograph mCT 64 PET/CT camera. In addition to lung tumors and lymph node diseases, abnormal tracer uptake in the patient's thyroid was also found. PET/CT also showed situs inversus totalis of the patient, including the dextrocardia, liver on the left side, stomach, and spleen on the right side of the patient's body. The identification of anatomical variations and abnormalities by PET/CT imaging is very important to develop the best treatment for lung cancer.

Keywords: 18 F-FDG; PET/CT; neuroendocrine carcinoma; situs inversus totalis; small cell lung cancer.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Chest imaging of positron emission tomography (PET)/CT scan. (A) There was high tracer uptake in the left hilar area. (B) The bronchus of the lower lobe of the left lung was truncated, and high tracer uptake was observed.
Figure 2
Figure 2
PET/CT scan showed that this was a patient with situs inversus totalis (SIT). (A,B) Axial PET, CT, and PET/CT fusion images show the dextrocardia (red area), liver on the left side (yellow area), stomach (white area), and spleen (green area) on the right side of the patient's body. (C) Coronal PET, CT, and PET/CT fusion images show the dextrocardia (red area), liver on the left side (yellow area), stomach (white area), and spleen (green area) on the right side of the patient's body.
Figure 3
Figure 3
PET/CT scan found that multiple lymph nodes also had high tracer uptake. Axial and coronal PET, CT, and PET/CT fusion images show tracer uptake in the mediastinum (A) Right hilar, (B) Gastric, (C) Liver, and (D) Lymph nodes.
Figure 4
Figure 4
PET / CT scan showed abnormalities of maxillary sinus and thyroid. (A) Axial and coronal PET, CT, and PET/CT fusion images show mucinous changes in the left maxillary sinus. (B) Axial and coronal PET, CT, and PET/CT fusion images showed abnormal tracer uptake in the patient's thyroid.
See this image and copyright information in PMC

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References

    1. Calabria FF, Leporace M, Bagnato A. Situs inversus totalis and cholangiocarcinoma of the gallbladder detected by 18F-FDG PET/CT. Clin Nucl Med. (2018) 43:439–40. 10.1097/RLU.0000000000002047 - DOI - PubMed
    1. Iwamura T, Shibata N, Haraguchi Y, Hisashi Y, Nishikawa T, Yamada H, et al. . Synchronous Double Cancer of the Stomach and Rectum With Situs Inversus Totalis and Polysplenia. Syndrome. (2001) 12:148–53. 10.1097/00004836-200108000-00012 - DOI - PubMed
    1. Halac M, Mut SS, Ylmaz S, Ergul N, Sonmezoglu K. Appearance of Situs Inversus Totalis and Polysplenia Syndrome on FDG PET/CT. Clin Nucl Med. (2008) 33:142–3. 10.1097/RLU.0b013e31815ef836 - DOI - PubMed
    1. Xie CL, Cai JS, Tan ZH, Yang J, Yang HX. Total minimally invasive mckeown esophagectomy in an esophageal cancer patient with situs inversus totalis: a case report. Thorac Cancer. (2021) 12:122–7. 10.1111/1759-7714.13723 - DOI - PMC - PubMed
    1. Zhang Y, Chen Y, Huang Z, Zhou F. Adenocarcinoma of the cervix uteri and endometrium combined with the kartagener syndrome on FDG PET/CT. Clin Nucl Med. (2015) 40:922–3. PubMed PMID: 26284775. 10.1097/RLU.0000000000000961 - DOI - PubMed

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