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Review
. 2022 Oct;15(5):1024-1048.
doi: 10.1007/s12265-022-10241-0. Epub 2022 Mar 31.

The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization

Cristiano Spadaccio  1   2 , Antonio Nenna  3 , David Rose  4 , Francesco Piccirillo  5 , Annunziata Nusca  5 , Francesco Grigioni  5 , Massimo Chello  3 , Gus J Vlahakes  6
Affiliations
Review

The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization

Cristiano Spadaccio et al. J Cardiovasc Transl Res. 2022 Oct.

Erratum in

Abstract

Surgical myocardial revascularization is associated with long-term survival benefit in patients with multivessel coronary artery disease. However, the exact biological mechanisms underlying the clinical benefits of myocardial revascularization have not been elucidated yet. Angiogenesis and arteriogenesis biologically leading to vascular collateralization are considered one of the endogenous mechanisms to preserve myocardial viability during ischemia, and the presence of coronary collateralization has been regarded as one of the predictors of long-term survival in patients with coronary artery disease (CAD). Some experimental studies and indirect clinical evidence on chronic CAD confirmed an angiogenetic response induced by myocardial revascularization and suggested that revascularization procedures could constitute an angiogenetic trigger per se. In this review, the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both CAD and coronary revascularization is analyzed with the aim to better elucidate their significance in the clinical arena and potential therapeutic use.

Keywords: Angiogenesis; Arteriogenesis; Coronary artery bypass graft; Myocardial infarction; Myocardial revascularization; Percutaneous coronary intervention.

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