Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments: 2020 Version
- PMID: 35357799
- Bookshelf ID: NBK579161
- DOI: 10.17226/26289
Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments: 2020 Version
Excerpt
The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) program develops human health assessments that focus on hazard identification and dose-response analyses for chemicals in the environment. The ORD Staff Handbook for Developing IRIS Assessments (the handbook) provides guidance to scientists who perform the IRIS assessments in order to foster consistency in the assessments and enhance transparency about the IRIS assessment process. At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties.
Copyright 2022 by the National Academy of Sciences. All rights reserved.
Sections
- The National Academies of SCIENCES • ENGINEERING • MEDICINE
- COMMITTEE TO REVIEW EPA'S IRIS ASSESSMENT HANDBOOK
- BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
- Acknowledgments
- Abbreviations and Acronyms
- Summary
- 1. Introduction
- 2. Overview of Organization and Content of the Handbook
- 3. Planning Assessments
- 4. Study Evaluation
- 5. Evidence Synthesis
- 6. Evidence Integration
- 7. Hazard Considerations and Study Selection for Deriving Toxicity Values
- REFERENCES
- Appendix A. Committee Member Biosketches
- Appendix B. 2020 IRIS Handbook Organization and Contents and EPA Questions to the Committee
- Appendix C. Open Session Agendas
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