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. 2022;95(3):286-290.
doi: 10.1159/000524350. Epub 2022 Mar 31.

Focal Epilepsy in Individuals with Laron Syndrome

Lotem Goldberg  1   2 , Zvi Laron  3   4 , Liora Kornreich  3   5 , Oded Scheuerman  6   3 , Hadassa Goldberg-Stern  3   7 , Dror Kraus  3   7
Affiliations

Focal Epilepsy in Individuals with Laron Syndrome

Lotem Goldberg et al. Horm Res Paediatr. 2022.

Abstract

Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS).

Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS.

Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications.

Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

Keywords: Epilepsy; Insulin-like growth factor-1; Laron syndrome; Seizures.

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Conflict of interest statement

No author has a potential conflict of interest in this manuscript.

Figures

Fig. 1
Fig. 1
Illustrative interictal EEG of patient #4, showing right posterior temporal spikes (traces #7, 8 at 1 and 5 s on double banana montage).
See this image and copyright information in PMC

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