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Review
. 2022 Mar 14:13:750494.
doi: 10.3389/fphar.2022.750494. eCollection 2022.

Traditional Knowledge to Contemporary Medication in the Treatment of Infectious Disease Dengue: A Review

Mamta Dhiman  1 , Lakshika Sharma  1 , Abhishek Dadhich  1 , Poonam Dhawan  2 , M M Sharma  1
Affiliations
Review

Traditional Knowledge to Contemporary Medication in the Treatment of Infectious Disease Dengue: A Review

Mamta Dhiman et al. Front Pharmacol. .

Abstract

Dengue has become a worldwide affliction despite incessant efforts to search for a cure for this long-lived disease. Optimistic consequences for dengue vaccine are implausible as the efficiency is tied to previous dengue virus (DENV) exposure and a very high cost is required for large-scale production of vaccine. Medicinal plants are idyllic substitutes to fight DENV infection since they constitute important components of traditional medicine and show antiviral properties, although the mechanism behind the action of bioactive compounds to obstruct viral replication is less explored and yet to be discovered. This review includes the existing traditional knowledge on how DENV infects and multiplies in the host cells, conscripting different medicinal plants that obtained bioactive compounds with anti-dengue properties, and the probable mechanism on how bioactive compounds modulate the host immune system during DENV infection. Moreover, different plant species having such bioactive compounds reported for anti-DENV efficiency should be validated scientifically via different in vitro and in vivo studies.

Keywords: bioactive compound; dengue; immunomodulatory response; plant medicaments; traditional medicine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Dengue infection cycle in human body.
FIGURE 2
FIGURE 2
(A) Dengue cases in different regions of India 2021. (B) State-wise distribution of dengue cases (y-axis) in four states of India from 2015 to 2021 (x-axis) (Source: National Vector Borne disease Control Programme).
FIGURE 3
FIGURE 3
(A) Comparative analysis of dengue incidences in different Asian countries (Source: WHO and European Center for disease Prevention and Control). (B) Number of dengue cases and deaths in India (2015–2021 May). (Source: National Vector Borne disease Control Programme).
See this image and copyright information in PMC

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