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Meta-Analysis
. 2022 Mar 10:13:848947.
doi: 10.3389/fendo.2022.848947. eCollection 2022.

Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Wenwen Yue  1 , Xin Huang  2 , Wenjing Zhang  1 , Shumin Li  3   4 , Xu Liu  1 , Yian Zhao  5 , Jiaxin Shu  5 , Teng Liu  2 , Weihua Li  6 , Shaozhuang Liu  2
Affiliations
Meta-Analysis

Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Wenwen Yue et al. Front Endocrinol (Lausanne). .

Abstract

Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease that is closely related to obesity. Metabolic surgery ameliorates a series of clinical manifestations and related comorbidities of PCOS. However, the overall efficacy of metabolic surgery on PCOS remains uncertain. This systematic review and meta-analysis aimed to evaluate the therapeutic effects of metabolic surgery on obese patients with PCOS. A systematic literature search for relevant studies was conducted on PubMed, Embase, Web of Science, and the Cochrane Library from inception to June 2021. Data extraction and quality evaluation were performed by three researchers, and RevMan 5.4 software was used to conduct the meta-analysis. A total of 14 studies involving 501 obese patients with PCOS were included. Incidence of PCOS in obese women ranged from 5.5% to 63.5% among the included studies. The results showed the incidence of abnormal menstruation decreased from 81% to 15% (OR=0.03, 95% confidence interval (CI): 0.01-0.08), while the incidence of hirsutism dropped from 71% to 38% (OR=0.21, 95% CI: 0.06-0.74). Serum total testosterone and free testosterone levels decreased by 25.92 ng/dL (MD = -25.92, 95% CI: -28.90- -22.93) and 2.28 ng/dL (SMD = -2.28, 95% CI: -3.67- -0.89), respectively. Sex hormone-binding globulin (SHBG) levels increased by 26.46 nmol/L (MD = 26.46, 95% CI: 12.97-39.95). Serum anti-Mullerian hormone (AMH) levels decreased by 1.29 ng/mL (MD = -1.29, 95% CI: -1.92- -0.66). Small sample size studies revealed that pregnancy rates ranged from 95.2% to 100% postoperatively. Metabolic surgery contributed to marked improvement of abnormal menstruation, hirsutism, and levels of free testosterone, total testosterone, SHBG, and AMH in patients with PCOS. Our findings indicate that patients with PCOS are expected to benefit from metabolic surgery, and could help potentially improve their reproductive outcomes. Metabolic surgery could thus be a new viable option for the clinical treatment of PCOS.

Systematic review registration: PROSPERO https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021251524.

Keywords: bariatric surgery; meta-analysis; metabolic surgery; obesity; polycystic ovary syndrome; systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA diagram of the systematic review.
Figure 2
Figure 2
Forrest plots showing changes of abnormal menstruation (A), hirsutism (B), total testosterone (C), and free testosterone (D) in women with PCOS after metabolic surgery.
Figure 3
Figure 3
Forrest plots showing changes of AMH (A), SHBG (B), and BMI (C) in women with PCOS after metabolic surgery.
Figure 4
Figure 4
Evaluate of publication bias by funnel plots of studies reporting on abnormal menstruation (A) and BMI (B).
See this image and copyright information in PMC

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