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. 2022 Mar 10:13:843573.
doi: 10.3389/fendo.2022.843573. eCollection 2022.

The Application Value of the Central Lymph Node Metastasis Risk Assessment Model in Papillary Thyroid Microcarcinoma of Stage cN0: A Study of 828 Patients

Jinqiu Wang  1 , Xianneng Sheng  1 , Yongping Dai  1 , Jiabo Zhang  1 , Lihua Song  2 , Yu Guo  1
Affiliations

The Application Value of the Central Lymph Node Metastasis Risk Assessment Model in Papillary Thyroid Microcarcinoma of Stage cN0: A Study of 828 Patients

Jinqiu Wang et al. Front Endocrinol (Lausanne). .

Abstract

Background: The aim of this study is to build a risk assessment system for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC) of stage cN0 and to explore its application value in clinical practice.

Methods: A total of 500 patients with PTMC who underwent thyroid operation from 2013 to 2015 in Ningbo First Hospital were selected as the model group. Independent risk factors related to CLNM in PTMC were analyzed and determined, and a risk assessment system for CLNM was preliminarily established. Furthermore, the clinicopathological data from 328 PTMC patients with the same conditions as the model group from 2016 to 2017 were further collected as the validation group to verify the diagnostic value of the risk assessment system.

Results: The risk assessment system was based on the score rating (score ≤ 5 was classified as low risk, 6-8 was classified as medium risk, and ≥9 was classified as high-risk). The area under the receiver operating characteristic curve (ROC) was 0.687 (95% CI: 0.635-0.783). According to the risk assessment system, 328 PTMC patients in the validation group were scored. Among the low-risk group, the moderate-risk group, and the high-group, 96.8%, 58.1%, and 43.2% were the CLNM (-) patients, and 3.1%, 41.9%, and 65.8% were CLNM (+) patients, respectively. The area under ROC was 0.837 (95% CI: 0.778-0.869).

Conclusions: The risk assessment system in this study is of diagnostic value and can provide a theoretical foundation for intraoperative decision-making of prophylactic central neck dissection (pCND).

Keywords: central lymph node dissection; central lymph node metastasis; papillary thyroid microcarcinoma; risk factors; surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Scatter plot of the relationship between the probability of occurrence (P) and risk score of CLNM.
Figure 2
Figure 2
ROC curve of risk factor scores in model group.
Figure 3
Figure 3
The distribution of CLNM-negative and positive patients with different risk scores inthe model group.
Figure 4
Figure 4
Validation group risk score ROC curve.
Figure 5
Figure 5
The distribution of CLNM-negative and positive patients with different risk scores inthe validation group.
See this image and copyright information in PMC

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