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. 2022 Jan-Dec:28:10760296221090227.
doi: 10.1177/10760296221090227.

Acute Myocardial Injury Assessed by High-Sensitive Cardiac Troponin Predicting Severe Outcomes and Death in Hospitalized Patients with COVID-19 Infection

Falmata Laouan Brem  1 , Miri Chaymae  1 , Hammam Rasras  1 , Manal Merbouh  2 , Mohammed-Amine Bouazzaoui  3 , Houssam Bkiyar  2 , Naima Abda  3 , Bazid Zakaria  1 , Nabila Ismaili  1   3 , Brahim Housni  2 , Noha El Ouafi  1   3
Affiliations

Acute Myocardial Injury Assessed by High-Sensitive Cardiac Troponin Predicting Severe Outcomes and Death in Hospitalized Patients with COVID-19 Infection

Falmata Laouan Brem et al. Clin Appl Thromb Hemost. 2022 Jan-Dec.

Abstract

Background: Cardiac injury has been linked to a poor prognosis during COVID-19 disease. Nevertheless, the risk factors associated are yet to be thoroughly investigated.

Objectives: We sought to compare demographical characteristics and in-hospital outcomes in patients infected by the SARS-CoV-2 with and without cardiac injury, to further investigate the prevalence of acute cardiac injury as well as its impact on their outcomes in COVID-19-patients.

Methods: We included in a retrospective analysis, all COVID-19 patients admitted between October first and December first, 2020, at the University Hospital Center of Oujda (Morocco) who underwent a troponin assay which was systematically measured on admission. The study population was divided into two groups: cardiac-injured patients and those without cardiac injury. Clinical, biological data and in-hospital outcomes were compared between the two groups.

Results: 298 confirmed COVID-19 cases were included. Our study found that compared to non-cardiac-injured, cardiac-injured patients are older, with higher possibilities of existing comorbidities including hypertension (68 [42.2%] vs 40 [29.2%], P = 0.02), diabetes (81 [50.3%] vs 53 [38.7%] P = 0.044), the need for mechanical ventilation, ICU admission and mortality. A Cox proportional hazards regression analysis shows a significantly increased risk of death among cardiac-injured COVID-19-patients as compared to non-cardiac injured. (HR, 1.620 [CI 95%: 2.562-1.024]).

Conclusion: Our retrospective cohort found that old age, comorbidities, a previous history of CAD, were significantly associated with acute cardiac injury. COVID-19 patients with acute cardiac injury are at a higher risk of ICU admission, and death.

Keywords: COVID-19; biomarkers; cardiology; mortality.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
A flow chart reporting numbers of individuals at each stage of study.
Figure 2.
Figure 2.
Electrocardiogram (EKG) of two patients with acute cardiac injury.
Figure 3.
Figure 3.
Kaplan-Meier survival curves for cardiac-injued and non-cardiac-injured hospitalized patients with COVID-19.
See this image and copyright information in PMC

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