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. 2022 Mar 31;17(1):25.
doi: 10.1186/s13011-022-00452-8.

Factors associated with take-home naloxone kit usage in British Columbia: an analysis of administrative data

Victor Lei  1 , Max Ferguson  2 , Rachael Geiger  1 , Sierra Williams  2 , Lisa Liu  2 , Jane A Buxton  3   4
Affiliations

Factors associated with take-home naloxone kit usage in British Columbia: an analysis of administrative data

Victor Lei et al. Subst Abuse Treat Prev Policy. .

Abstract

Background: The British Columbia (BC) Take-Home Naloxone (THN) program provides naloxone to people at risk of experiencing or witnessing an opioid overdose for use in reversing suspected overdose events. This study seeks to examine trends and correlates of individuals obtaining a THN kit in BC between 2017 and 2020.

Methods: Records of THN kits distributed between 2017 and 2020 were the primary source of data for this analysis. Frequency tables were used to describe characteristics of people obtaining kits from THN sites. Correlates of individuals obtaining a THN kit to replace a previous kit reported as used to reverse an overdose were assessed with multivariate logistic regression.

Results: Between January 1, 2017, and December 31, 2020, 240,606 THN kits were reported distributed by registered sites to members of the public, with 90,011 records indicating that a kit was obtained to replace a previous kit that had been used to reverse an overdose. There was a significant trend in increasing kits reported used by year (p < 0.01). The kit recipient's risk of overdose was a significant predictor of having reported using a THN kit, and the strength of the association was dependent on gender (Male: Adjusted odds ratio (AOR) 5.37 [95% confidence interval (CI) 5.08 - 5.67]; Female: AOR 8.35 [95% CI 7.90 - 8.82]; Trans and gender expansive: AOR 3.68 [95% CI 2.82 - 4.79]).

Conclusions: Between 2017 and 2020, THN kits were used to reverse tens of thousands of overdose events in BC, with people at risk of overdose (i.e. people who use drugs [PWUD]) having greater odds of using a kit to reverse an overdose than those not at risk. Thus, PWUD are responsible for reversing the vast majority of overdoses. THN kits are being distributed to the people who use them most. However, additional strategies in conjunction with community-based naloxone distribution programs are needed to address the rising number of illicit drug toxicity deaths.

Keywords: Harm reduction; Naloxone; Opioid antagonist; Overdose; Take-home naloxone; Toxicity.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study samples for sub-analyses from BC Take-Home Naloxone distribution records from January 1, 2017 to December 31, 2020
See this image and copyright information in PMC

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