doi: 10.1111/j.1365-2222.1986.tb01977.x.
Associations between asthma history, atopy, and non-specific bronchial responsiveness in young adults
- PMID: 3536170
- DOI: 10.1111/j.1365-2222.1986.tb01977.x
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Associations between asthma history, atopy, and non-specific bronchial responsiveness in young adults
Clin Allergy.
1986 Sep.
Abstract
In 105 subjects taken from a student population and aged between 15 and 30 there was a strong positive association between the presence of the atopic state, defined by skin tests, and a high level of non-specific bronchial responsiveness to methacholine (chi 2 = 10.5, d.f. = 2, P = 0.01). Regression analysis showed a history of asthma, and the symptom of wheeze, to be predominantly predicted by the degree of bronchial responsiveness (R2 = 31%), with only a minor independent contribution from the degree of atopy (R2 a further 5%). The genetic or other reasons for the association between bronchial responsiveness and atopy may have importance in understanding the aetiology of allergic asthma.
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