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. 2022 Jun;19(6):347-348.
doi: 10.1038/s41575-022-00609-7.

The tumour-associated microbiome

Christopher D Johnston  1 , Susan Bullman  2
Affiliations

The tumour-associated microbiome

Christopher D Johnston et al. Nat Rev Gastroenterol Hepatol. 2022 Jun.

Abstract

The burgeoning field of intratumoural microbiome research has been driven by advances in next-generation sequencing technologies, with compelling evidence on the role of the microbiota in cancer initiation, progression and patient response to treatment. Here, we discuss new concepts of the tumour-associated microbiota and what is needed to advance the translational impact of these findings in gastrointestinal cancers.

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Conflict of interest statement

Competing interests

C.D.J. has consulted for Seres Therapeutics and Azitra. S.B. has consulted for GlaxoSmithKline and BioMx; and is on the cancer programme advisory board for BioMx.

Figures

Fig. 1 |
Fig. 1 |. The tumour-associated microbiota.
The schematic shows the key components of the tumour microenvironment, including a resident microbiota.
See this image and copyright information in PMC

References

    1. Poore GD et al. Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature 579, 567–574 (2020). - PMC - PubMed
    1. Nejman D et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368, 973–980 (2020). - PMC - PubMed
    1. Bullman S et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 358, 1443–1448 (2017). - PMC - PubMed
    1. Johnston CD et al. Systematic evasion of the restriction-modification barrier in bacteria. Proc. Natl Acad. Sci. USA 116, 11454–11459 (2019). - PMC - PubMed
    1. Kalaora S et al. Identification of bacteria-derived HLA-bound peptides in melanoma. Nature 592, 138–143 (2021). - PMC - PubMed

Publication types