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Multicenter Study
. 2022 Aug;29(8):950-959.
doi: 10.1002/jhbp.1144. Epub 2022 Apr 20.

Detection rate of endoscopic ultrasound and computed tomography in diagnosing pancreatic neuroendocrine neoplasms including small lesions: A multicenter study

Yusuke Kurita  1   2 , Kazuo Hara  2 , Noritoshi Kobayashi  3 , Takamichi Kuwahara  2 , Nobumasa Mizuno  2 , Nozomi Okuno  2 , Shin Haba  2 , Shin Yagi  1 , Sho Hasegawa  1 , Takamitsu Sato  1 , Kunihiro Hosono  1 , Itaru Endo  4 , Yasuhiro Shimizu  5 , Yasumasa Niwa  6 , Daisuke Utsunomiya  7 , Yoshitaka Inaba  8 , Atsushi Nakajima  1 , Kensuke Kubota  1 , Yasushi Ichikawa  3
Affiliations
Multicenter Study

Detection rate of endoscopic ultrasound and computed tomography in diagnosing pancreatic neuroendocrine neoplasms including small lesions: A multicenter study

Yusuke Kurita et al. J Hepatobiliary Pancreat Sci. 2022 Aug.

Abstract

Background/purpose: The detection ability and role of different imaging modalities to detect pancreatic neuroendocrine neoplasms (PNENs) including small lesions is unclear. This study aimed to compare the ability of endoscopic ultrasound (EUS) and computed tomography (CT) to detect PNENs.

Methods: Data of patients who underwent EUS and contrast-enhanced CT and were diagnosed with PNENs were analyzed. The detection rates of pancreatic lesions with EUS and CT based on tumor size and influencing factors were investigated.

Results: For 256 PNEN lesions, the detection rate of EUS was better than that of CT (94.5% vs 86.3%; P < .001). EUS was significantly superior to CT for PNENs ≤5 mm (58.3% vs 16.7%; P = .006) and 5-10 mm (97.7% vs 79.5%; P = .008). There was no significant difference in the detection rate between EUS and CT for PNENs >10 mm (98.4% vs 96.4%; P = .375). Size (≤5 mm) and insulinoma were independent factors associated with poor EUS and CT detection rates.

Conclusions: Endoscopic ultrasound exhibited better detection ability than CT, with an excellent detection rate for PNENs >5 mm, except for insulinomas. CT could detect PNENs >10 mm, which are amenable to treatment.

Keywords: computed tomography; endoscopic ultrasound; insulinoma; pancreatic neuroendocrine neoplasms.

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References

REFERENCES

    1. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063-72.
    1. Heitz PU, Kasper M, Polak JM, Klöppel G. Pancreatic endocrine tumors. Hum Pathol. 1982;13:263-71.
    1. Ito T, Igarashi H, Nakamura K, Sasano H, Okusaka T, Takano K, et al. Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis. J Gastroenterol. 2015;50:58-64.
    1. Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, et al. NCCN guidelines insights: neuroendocrine and adrenal tumors, version 2.2018. 2018;16:693.
    1. Anderson MA, Carpenter S, Thompson NW, Nostrant TT, Elta GH, Scheiman JM. Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. Am J Gastroenterol. 2000;95:2271-7.

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