Platelets and mast cells say "HIAA" to welcome in neutrophils

Affiliations

Comment

Andrew Lichtman. Sci Immunol. 2022 Apr.

. 2022 Apr;7(70):eabq1730.

doi: 10.1126/sciimmunol.abq1730. Epub 2022 Apr 1.

¹ Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Email: alichtman@bwh.harvard.edu.

Abstract

Platelet- and mast cell-derived serotonin metabolite 5-HIAA binding to GPR35 mediates neutrophil recruitment to acute inflammatory sites.

GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. De Giovanni M, et al. Cell. 2022 Mar 3;185(5):815-830.e19. doi: 10.1016/j.cell.2022.01.010. Epub 2022 Feb 10. Cell. 2022. PMID: 35148838 Free PMC article.