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Editorial
. 2021 Dec 1;11(12):2962-2964.
doi: 10.1158/2159-8290.CD-21-1222.

A Tale of Two Histologies: Dissecting the Biology of Lineage Transformation in Lung Cancer

Catherine B Meador  1 , Christine M Lovly  2
Affiliations
Editorial

A Tale of Two Histologies: Dissecting the Biology of Lineage Transformation in Lung Cancer

Catherine B Meador et al. Cancer Discov. .

Abstract

Lineage plasticity is an important, and likely underappreciated, mechanism of treatment resistance in lung cancer. Here, Quintanal-Villalonga and colleagues integrate results from multiomic analyses to provide key new insights into the biology of lineage plasticity. See related article by Quintanal-Villalonga et al., p. 3028.

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Figures

Figure 1.
Figure 1.. Bench to bedside framework for conceptualizing neuroendocrine lineage plasticity in lung cancer.
Schematized representation summarizing current data regarding lineage transformation in lung cancer. For clarity, arrows are one-directional, but no data exist yet to definitively prove directionality. Note that this figure is focused on EGFR-mutant SCLC transformation, but evidence of lineage transformation in non-EGFR-mutant contexts is emerging, as referenced in the text. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation.
    Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Manoj P, Donoghue MTA, Won HH, Chan JM, Ciampricotti M, Chow A, Offin M, Chang JC, Ray-Kirton J, Tischfield SE, Egger J, Bhanot UK, Linkov I, Asher M, Sinha S, Silber J, Iacobuzio-Donahue CA, Roehrl MH, Hollmann TJ, Yu HA, Qiu J, de Stanchina E, Baine MK, Rekhtman N, Poirier JT, Loomis B, Koche RP, Rudin CM, Sen T. Quintanal-Villalonga A, et al. Cancer Discov. 2021 Dec 1;11(12):3028-3047. doi: 10.1158/2159-8290.CD-20-1863. Cancer Discov. 2021. PMID: 34155000 Free PMC article.

References

    1. Zakowski MF, Ladanyi M & Kris MG EGFR mutations in small-cell lung cancers in patients who have never smoked. N Engl J Med 355, 213–215 (2006). - PubMed
    1. Iams WT, Beckermann KE, Almodovar K, Hernandez J, Vnencak-Jones C, Lim LP, et al. Small Cell Lung Cancer Transformation as a Mechanism of Resistance to PD-1 Therapy in KRAS-Mutant Lung Adenocarcinoma: A Report of Two Cases. J Thorac Oncol 14, e45–e48 (2019). - PMC - PubMed
    1. Cha YJ, Cho BC, Kim HR, Lee HJ & Shim HS A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib. J Thorac Oncol 11, e55–e58 (2016). - PubMed
    1. Beltran H, Prandi D, Mosquera JM, Benelli M, Puca L, Cyrta J, et al. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat Med 22, 298–305 (2016). - PMC - PubMed
    1. Quintanal-Villalonga A TH, Zhan Y, Hasan MM, Chavan SS, Meng F, et al. Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation. Cancer Discov. - PMC - PubMed